3-(2-chloro-4-methylphenyl)-2-methylpropanoyl chloride

Base Information

• Chemical Name: 3-(2-chloro-4-methylphenyl)-2-methylpropanoyl chloride
• CAS No.: 1613641-70-5
• Molecular Formula: C₁₁H₁₂Cl₂O
• Molecular Weight: 231.122
• Mol file: 1613641-70-5.mol

Synonyms:3-(2-chloro-4-methylphenyl)-2-methylpropanoyl chloride

Chemical Property of 3-(2-chloro-4-methylphenyl)-2-methylpropanoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-chloro-4-methylphenyl)-2-methylpropanoyl chloride

There total 7 articles about 3-(2-chloro-4-methylphenyl)-2-methylpropanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-chloro-1-(chloromethyl)-4-methylbenzene (2719-39-3) + Diethyl methylmalonate (609-08-5) → 3-(2-chloro-4-methylphenyl)-2-methylpropanoyl chloride (1613641-70-5)

Guidance literature:

Diethyl methylmalonate; With sodium ethanolate; for 0.25h;

2-chloro-1-(chloromethyl)-4-methylbenzene; for 2h; Further stages; Reflux;

Reference yield:

C11H13ClO2 (1506521-66-9) → 3-(2-chloro-4-methylphenyl)-2-methylpropanoyl chloride (1613641-70-5)

Guidance literature:

With thionyl chloride; at 20 ℃; for 24h; Inert atmosphere; Schlenk technique; Glovebox;

Reference yield:

2-chloro-4-methyl-benzaldehyde (50817-80-6) → 3-(2-chloro-4-methylphenyl)-2-methylpropanoyl chloride (1613641-70-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0 - 20 °C / Inert atmosphere; Schlenk technique; Glovebox

2.1: thionyl chloride / dichloromethane / 5 - 20 °C / Inert atmosphere; Schlenk technique; Glovebox

3.1: sodium ethanolate / ethanol / 0.25 h / Inert atmosphere; Schlenk technique; Glovebox

3.2: 2 h / Inert atmosphere; Schlenk technique; Glovebox; Reflux

3.3: 4 h / Inert atmosphere; Schlenk technique; Glovebox; Reflux

4.1: 160 - 180 °C / Inert atmosphere; Schlenk technique; Glovebox

5.1: thionyl chloride / 24 h / 20 °C / Inert atmosphere; Schlenk technique; Glovebox

With sodium tetrahydroborate; thionyl chloride; sodium ethanolate; In tetrahydrofuran; methanol; ethanol; dichloromethane;

upstream raw materials:

C₁₁H₁₃ClO₂

2-chloro-4-methyl-benzaldehyde

1-bromo-2-chloro-4-methylbenzene

(2-chloro-4-methylphenyl)methanol