4,6-dichloro-5-(4-chlorophenyl)-pyriMidine

Base Information

Chemical Name:4,6-dichloro-5-(4-chlorophenyl)-pyriMidine
CAS No.:3974-18-3
Molecular Formula:C10H5Cl3N2
Molecular Weight:259.51900
Hs Code.:
Mol file:3974-18-3.mol

Synonyms:4,6-dichloro-5-(4-chlorophenyl)-pyrimidine;Pyrimidine,4,6-dichloro-5-(4-chlorophenyl);4,6-Dichlor-5-(4-chlorphenyl)-pyrimidin;4,6-dichloro-5-(p-chlorophenyl)pyrimidine;

Suppliers and Price of 4,6-dichloro-5-(4-chlorophenyl)-pyriMidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of 4,6-dichloro-5-(4-chlorophenyl)-pyriMidine

Chemical Property:

Boiling Point:348.9±42.0 °C(Predicted)
PKA:-4.92±0.26(Predicted)
PSA：25.78000
Density:1.466±0.06 g/cm3(Predicted)
LogP:4.10380
Storage Temp.:2-8°C

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4,6-dichloro-5-(4-chlorophenyl)-pyriMidine

There total 5 articles about 4,6-dichloro-5-(4-chlorophenyl)-pyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 3979-80-4
5-(4-chlorophenyl)pyrimidine-4,6-diol

: 3974-18-3
4,6-dichloro-5-(4-chlorophenyl)-pyrimidine

Guidance literature:: With trichlorophosphate; at 90 ℃;
DOI:10.1016/j.bmc.2006.12.029

Reference yield:

: 1878-66-6
4-chlorophenylacetic Acid

: 3974-18-3
4,6-dichloro-5-(4-chlorophenyl)-pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / conc. HCl / Heating

2: 64 percent / NaH / hexane; tetrahydrofuran / 60 °C

3: 81 percent / NaOMe / methanol / 60 °C

4: 62 percent / POCl₃ / 90 °C

With hydrogenchloride; sodium methylate; sodium hydride; trichlorophosphate; In tetrahydrofuran; methanol; hexane;
DOI:10.1016/j.bmc.2006.12.029

Reference yield:

: 52449-43-1
(4-chloro-phenyl)-acetic acid methyl ester

: 3974-18-3
4,6-dichloro-5-(4-chlorophenyl)-pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / NaH / hexane; tetrahydrofuran / 60 °C

2: 81 percent / NaOMe / methanol / 60 °C

3: 62 percent / POCl₃ / 90 °C

With sodium methylate; sodium hydride; trichlorophosphate; In tetrahydrofuran; methanol; hexane;
DOI:10.1016/j.bmc.2006.12.029