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High quality 4-Chlorophenylacetic Acid supplier in China
Cas No: 1878-66-6
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High quality 4-Chlorophenylacetic Acid supplier CAS NO.1878-66-6
Cas No: 1878-66-6
USD $ 250.0-250.0 / Gram 500 Gram 100 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
4-Chlorophenylacetic acid Cas 1878-66-6
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4-Chlorophenylacetic acid
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USD $ 5.0-5.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Enke Pharma-tech Co.,Ltd. (Cangzhou, China ) Contact Supplier
4-Chlorophenylacetic acid
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4-Chlorophenylacetic acid
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TIANFU-CHEM 4-Chlorophenylacetic acid 1878-66-6
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BLOOM TECH Advanced API/Technology support 2-(4-Chlorophenyl)acetic acid CAS 1878-66-6
Cas No: 1878-66-6
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1878-66-6 Usage

Definition

ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-chlorophenyl group.

Uses

4-Chlorophenylacetic Acid is a chlorinated phenyl acetic acid that is an antitumor differentiation inducer and may be an effective therapeutic agent in neuroblastoma therapy. 4-Chlorophenylacetic Acid shows plant growth-regulating activity.

Chemical Properties

white to cream colored powder

Purification Methods

Purify it as for 3-chlorophenylacetic acid. [Beilstein 9 III 2263, 9 IV 1674.]
InChI:InChI=1/C8H7ClO2/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4H,5H2,(H,10,11)/p-1

1878-66-6 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A14974)  4-Chlorophenylacetic acid, 98%    1878-66-6 1000g 3833.0CNY Detail
Alfa Aesar (A14974)  4-Chlorophenylacetic acid, 98%    1878-66-6 250g 1049.0CNY Detail
Alfa Aesar (A14974)  4-Chlorophenylacetic acid, 98%    1878-66-6 50g 277.0CNY Detail

1878-66-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-chlorophenylacetic acid

1.2 Other means of identification

Product number -
Other names (4-Chlorophenyl)acetic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1878-66-6 SDS

1878-66-6Synthetic route

p-chlorobenzyl cyanide
140-53-4

p-chlorobenzyl cyanide

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With water; sodium hydroxide at 110 - 116℃; under 15001.5 Torr; for 0.05h; Concentration; Pressure; Temperature; Flow reactor;99%
With 1-butyl-3-methylimidazolium hydrogen sulfate; water at 60 - 65℃; for 1.1h; Green chemistry;96%
With potassium hydroxide In toluene at 160℃; for 0.5h; microwave irradiation;92%
4-chloro-benzeneacetic acid, ethyl ester
14062-24-9

4-chloro-benzeneacetic acid, ethyl ester

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With water; sodium hydroxide In 1,4-dioxane at 60℃; for 2h; pH=10 - 14;98%
carbon monoxide
201230-82-2

carbon monoxide

4-chlorobenzyl bromide
622-95-7

4-chlorobenzyl bromide

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium iodide In formic acid at 60℃; under 760 Torr; for 18h; Carbonylation;95%
With cobalt(II) pyridine-2-carboxylate; palladium diacetate; sodium hydroxide In methanol at 180℃; under 11251.1 Torr; for 6h; Temperature; Reagent/catalyst; Autoclave;95.2%
With palladium hydroxide, 20 wt% on carbon; tetrabutylammomium bromide; water In tetrahydrofuran at 110℃; under 7500.75 Torr; for 4h; Sealed tube; Autoclave;79%
With sodium hydroxide; sodium tetrahydroborate In tetrahydrofuran at 55℃; for 3h;78%
N-[(E)-2-(4-Chloro-phenyl)-1-cyano-vinyl]-4,N-dimethyl-benzamide
89244-19-9, 89244-20-2

N-[(E)-2-(4-Chloro-phenyl)-1-cyano-vinyl]-4,N-dimethyl-benzamide

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran for 6h; Heating;95%
C14H21ClNO3P

C14H21ClNO3P

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With hydrogen bromide at 100℃; for 0.166667h;95%
With water; hydrogen bromide at 100℃; for 0.166667h; Inert atmosphere;95%
4-Methoxybenzyl 2-(4-chlorophenyl)acetate
1575722-27-8

4-Methoxybenzyl 2-(4-chlorophenyl)acetate

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With proton-exchanged montmorillonite In dichloromethane at 20℃;95%
2-(4-chlorophenyl)-1-(pyrrolidin-1-yl)-ethanone
19202-19-8

2-(4-chlorophenyl)-1-(pyrrolidin-1-yl)-ethanone

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane for 30h; Heating;94%
1-Chloro-4-(chloromethyl)benzene
104-83-6

1-Chloro-4-(chloromethyl)benzene

butan-1-ol
71-36-3

butan-1-ol

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
Stage #1: butan-1-ol With cobalt(II) sulfate at 80℃; under 3750.38 Torr; for 4h; Autoclave;
Stage #2: 1-Chloro-4-(chloromethyl)benzene With sodium hydroxide In water at 80℃; under 3750.38 Torr; for 24h; Concentration; Pressure; Temperature; Autoclave;
93.6%
carbon monoxide
201230-82-2

carbon monoxide

1-chloro-4-(dibromomethyl)benzene
62037-06-3

1-chloro-4-(dibromomethyl)benzene

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With potassium hydroxide; dicobalt octacarbonyl; N-benzyl-N,N,N-triethylammonium chloride In benzene under 760 Torr; for 8h; Ambient temperature;92%
(4-chloro-phenyl)-acetic acid methyl ester
52449-43-1

(4-chloro-phenyl)-acetic acid methyl ester

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With sodium hydroxide for 2h; Heating;92%
With potassium hydroxide In methanol for 4h; Ambient temperature;50%
With water for 36h;50%
4-chloro-N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)phenylglycinonitrile

4-chloro-N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)phenylglycinonitrile

A

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

B

N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)amine
888963-33-5

N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)amine

Conditions
ConditionsYield
With hydrogen bromide; acetic acid In dichloromethane; water at 20℃; for 1h;A 92%
B n/a
carbon monoxide
201230-82-2

carbon monoxide

1-Chloro-4-(chloromethyl)benzene
104-83-6

1-Chloro-4-(chloromethyl)benzene

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With cobalt(II) pyridine-2-carboxylate; palladium diacetate; sodium hydroxide In methanol at 180℃; under 11251.1 Torr; for 6h; Temperature; Reagent/catalyst; Solvent; Autoclave;90%
Stage #1: carbon monoxide With C28H22CoN4O6 In butan-1-ol at 60℃; under 760.051 Torr; for 2h; Glovebox; High pressure; Green chemistry;
Stage #2: 1-Chloro-4-(chloromethyl)benzene With tetra-(n-butyl)ammonium iodide; sodium hydroxide In butan-1-ol at 60℃; under 760.051 Torr; for 22h; Glovebox; High pressure; Green chemistry; regioselective reaction;
86%
With bis-triphenylphosphine-palladium(II) chloride; tetraethylammonium chloride; sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene at 80℃; under 11251.1 Torr; for 20h; Autoclave; regioselective reaction;86%
With sodium hydroxide; cerium(III) chloride; cetyltrimethylammonim bromide; nickel cyanide In toluene at 85 - 95℃; under 1 Torr; for 6.5h;82%
With water; palladium diacetate at 110℃; under 37503.8 Torr; for 4h; Ionic liquid;84 %Chromat.
2-(4-chlorophenyl)-1-(morpholin-4-yl)-ethanethione
42945-85-7

2-(4-chlorophenyl)-1-(morpholin-4-yl)-ethanethione

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With sodium hydroxide for 0.0166667h; microwave irradiation;90%
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride at 100℃; for 8h;
1-Chloro-4-(chloromethyl)benzene
104-83-6

1-Chloro-4-(chloromethyl)benzene

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With sodium hydroxide; cobalt tetracarbonyl anion In methanol at 55℃; for 4h;84%
Multi-step reaction with 2 steps
1: dimethylsulfoxide / 5 h / 45 - 50 °C
2: KOH / aq. ethanol / Heating
View Scheme
Multi-step reaction with 2 steps
1: alcohol / 120 - 130 °C / im Druckrohr
2: concentrated KOH-solution
View Scheme
Multi-step reaction with 2 steps
1: alcohol; water
2: concentrated KOH-solution
View Scheme
Multi-step reaction with 2 steps
1: ethanol; H2O / Heating
2: aq. KOH / ethanol / Heating
View Scheme
carbon dioxide
124-38-9

carbon dioxide

(4-chlorobenzylidene)hydrazine
52372-80-2

(4-chlorobenzylidene)hydrazine

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; caesium carbonate; cesium fluoride In N,N-dimethyl-formamide at 80℃; under 760.051 Torr; for 24h; chemoselective reaction;82%
4-vinylbenzyl chloride
1073-67-2

4-vinylbenzyl chloride

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With Oxone; iodine In 1,2-dimethoxyethane; water at 20℃; for 3h; regioselective reaction;77%
With D-glucose; oxygen In aq. phosphate buffer at 30℃; for 10h; pH=8; Green chemistry; Enzymatic reaction; regioselective reaction;75%
carbon monoxide
201230-82-2

carbon monoxide

1-chloro-4-(dibromomethyl)benzene
62037-06-3

1-chloro-4-(dibromomethyl)benzene

A

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

B

4,4'-dichlorostylbene
5121-74-4

4,4'-dichlorostylbene

Conditions
ConditionsYield
With potassium hydroxide; dicobalt octacarbonyl; 18-crown-6 ether; N-benzyl-N,N,N-triethylammonium chloride In benzene under 760 Torr; for 8h; Product distribution; Ambient temperature; other reagent systems, other temp., various benzal bromides;A 70%
B 12%
With potassium hydroxide; dicobalt octacarbonyl; 18-crown-6 ether In benzene under 760 Torr; for 8h; Ambient temperature;A 32%
B 39%
1-chloro-4-(2,2-dibromovinyl)benzene
77295-59-1

1-chloro-4-(2,2-dibromovinyl)benzene

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
Stage #1: 1-chloro-4-(2,2-dibromovinyl)benzene With n-butyllithium In tetrahydrofuran at 0℃; for 1.5h;
Stage #2: With 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In tetrahydrofuran for 2h;
67%
With PEG-400; potassium hydroxide; bis[1,2-bis(diphenylphosphino)ethane]palladium(0) In dichloromethane at 60 - 65℃; for 17h;56%
Multi-step reaction with 2 steps
1: 91 percent / H2O / ethyl acetate / 8 h / 20 °C
2: 94 percent / aq. HCl / dioxane / 30 h / Heating
View Scheme
p-chlorobenzyl cyanide
140-53-4

p-chlorobenzyl cyanide

A

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

B

2-(4-chlorophenyl)acetamide
20101-92-2

2-(4-chlorophenyl)acetamide

Conditions
ConditionsYield
With potassium hydroxide In toluene at 160℃; for 0.166667h; microwave irradiation;A 65%
B 32%
With immobilized activated nitrilase In water Rate constant; Ambient temperature; effect of β-cyclodextrin;
2-[(4-chlorophenyl)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
517920-59-1

2-[(4-chlorophenyl)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

carbon dioxide
124-38-9

carbon dioxide

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With potassium ethoxide In 1,4-dioxane at 100℃; for 24h;65%
1-Chloro-4-iodobenzene
637-87-6

1-Chloro-4-iodobenzene

acetic acid
64-19-7

acetic acid

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With silver(I) acetate; sodium acetate; palladium dichloride at 130℃; for 24h; Schlenk technique; Inert atmosphere; chemoselective reaction;63%
lead(II) thiocyanate
592-87-0

lead(II) thiocyanate

((2-(4-chlorophenyl)-1-methoxyvinyl)oxy)trimethylsilane

((2-(4-chlorophenyl)-1-methoxyvinyl)oxy)trimethylsilane

A

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

B

methyl 2-(4-chlorophenyl)-2-thiocyanatoethanoate

methyl 2-(4-chlorophenyl)-2-thiocyanatoethanoate

Conditions
ConditionsYield
Stage #1: lead(II) thiocyanate With (Dichloroiodo)benzene In dichloromethane at 0℃; for 0.333333h;
Stage #2: ((2-(4-chlorophenyl)-1-methoxyvinyl)oxy)trimethylsilane In dichloromethane at 0 - 20℃; Further stages.;
A 10%
B 57%
hypofluorous acid trifluoromethyl ester
373-91-1

hypofluorous acid trifluoromethyl ester

4-(4-chlorobenzylidene)-2,2,6,6-tetramethyl-3,5-dioxa-2,6-disilaheptane
75581-01-0

4-(4-chlorobenzylidene)-2,2,6,6-tetramethyl-3,5-dioxa-2,6-disilaheptane

A

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

B

4-chloro-α-fluorobenzeneacetic acid
74590-69-5

4-chloro-α-fluorobenzeneacetic acid

Conditions
ConditionsYield
In CFCl3; hexane; waterA 53%
B n/a
formic acid
64-18-6

formic acid

1-Chloro-4-(chloromethyl)benzene
104-83-6

1-Chloro-4-(chloromethyl)benzene

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With N,N,N,N,-tetramethylethylenediamine; α,α′-bis(2-pyridyl(tert-butyl)phosphino)-o-xylene; palladium diacetate In N,N-dimethyl-formamide at 115℃; for 24h; Inert atmosphere;53%
cis-2,3-epoxy-3-(4-chlorophenyl)propanenitrile
33984-97-3, 33984-98-4

cis-2,3-epoxy-3-(4-chlorophenyl)propanenitrile

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; water In 1,4-dioxane at 175℃; for 0.5h; Microwave irradiation; Green chemistry;52%
2-(4-Chlorophenyl)ethanol
1875-88-3

2-(4-Chlorophenyl)ethanol

A

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

B

2-phenylethanol
60-12-8

2-phenylethanol

C

benzoic acid
65-85-0

benzoic acid

D

para-chlorobenzoic acid
74-11-3

para-chlorobenzoic acid

Conditions
ConditionsYield
With sodium hydroxide; oxygen; lead acetate; palladium on activated charcoal In water at 90℃; under 3800 Torr; for 3h;A 36.5%
B 36.8%
C 3%
D 4.7%
p-chlorophenacyl chloride
937-20-2

p-chlorophenacyl chloride

A

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

B

1,4-bis(4-chlorophenyl)butane-1,4-dione
24314-35-0

1,4-bis(4-chlorophenyl)butane-1,4-dione

C

para-chloroacetophenone
99-91-2

para-chloroacetophenone

Conditions
ConditionsYield
With methyloxirane In water; acetonitrile for 4h; Irradiation;A 35%
B 18%
C 6%
With methyloxirane In water; acetone for 4h; Irradiation;A 14%
B 31%
C 10%
carbon dioxide
124-38-9

carbon dioxide

para-chlorotoluene
106-43-4

para-chlorotoluene

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With bis(2-pyridyl)methane; xanth-9-one; nickel(II) chloride hexahydrate; potassium tert-butylate In benzene at 20℃; under 760.051 Torr; for 4h; Irradiation; Schlenk technique;33%
5-p-chlorophenyl-2-phenyl-4-tosyl-2-oxazoline
80225-01-0

5-p-chlorophenyl-2-phenyl-4-tosyl-2-oxazoline

A

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

B

5-(4-chlorophenyl)-2-phenyl-1,3-oxazole
80224-89-1

5-(4-chlorophenyl)-2-phenyl-1,3-oxazole

C

p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

D

benzamide
55-21-0

benzamide

Conditions
ConditionsYield
With potassium carbonate In methanol for 1.5h; Heating; Yields of byproduct given;A n/a
B 14%
C n/a
D n/a
3-(5-aminomethyl-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione hydrochloride

3-(5-aminomethyl-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione hydrochloride

2-picolinoyl chloride hydrochloride
39901-94-5

2-picolinoyl chloride hydrochloride

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.25h;10%
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

methanol
67-56-1

methanol

(4-chloro-phenyl)-acetic acid methyl ester
52449-43-1

(4-chloro-phenyl)-acetic acid methyl ester

Conditions
ConditionsYield
With hydrogenchloride for 1h; Heating;100%
With monoammonium 12-tungstophosphate for 12h; Heating;98%
With sulfuric acid at 0 - 5℃; for 4.16667h; Reflux;98%
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

ethanol
64-17-5

ethanol

4-chloro-benzeneacetic acid, ethyl ester
14062-24-9

4-chloro-benzeneacetic acid, ethyl ester

Conditions
ConditionsYield
With sulfuric acid In benzene for 6h; Reflux;100%
sulfuric acid at 20℃;99%
With monoammonium 12-tungstophosphate for 12h; Heating;98%
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

4-chlorophenacetyl chloride
25026-34-0

4-chlorophenacetyl chloride

Conditions
ConditionsYield
With thionyl chloride In dichloromethane100%
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 23℃;100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 18h;90%
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

benzaldehyde
100-52-7

benzaldehyde

(2E)-2-(4-chlorophenyl)-3-phenylprop-2-enoic acid
10465-70-0, 73720-02-2, 20432-20-6

(2E)-2-(4-chlorophenyl)-3-phenylprop-2-enoic acid

Conditions
ConditionsYield
With acetic anhydride; triethylamine100%
In acetic anhydride
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

2,4-diaminophenol dihydrochloride
137-09-7

2,4-diaminophenol dihydrochloride

2-(4-chlorobenzyl)-5-aminobenzoxazole
381200-35-7

2-(4-chlorobenzyl)-5-aminobenzoxazole

Conditions
ConditionsYield
With PPA at 195 - 198℃; for 1.5h;100%
With polyphosphoric acid at 200℃; for 1.5h;75%
With PPA Heating;
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

2,4-diaminophenol
95-86-3

2,4-diaminophenol

2-(4-chlorobenzyl)-5-aminobenzoxazole
381200-35-7

2-(4-chlorobenzyl)-5-aminobenzoxazole

Conditions
ConditionsYield
With PPA at 195 - 198℃; for 1.5h;100%
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

methyl iodide
74-88-4

methyl iodide

(4-chloro-phenyl)-acetic acid methyl ester
52449-43-1

(4-chloro-phenyl)-acetic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In acetone at 60℃;100%
With potassium carbonate In acetone at 60℃;100%
Stage #1: 4-chlorophenylacetic Acid With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 20℃; for 1h;
Stage #2: methyl iodide In toluene at 20℃; for 48h;
50%
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

N-cyclohexyl-cyclohexanamine
101-83-7

N-cyclohexyl-cyclohexanamine

C8H7ClO2*C12H23N

C8H7ClO2*C12H23N

Conditions
ConditionsYield
In methanol at 20℃;100%
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

ethyl iodide
75-03-6

ethyl iodide

4-chloro-benzeneacetic acid, ethyl ester
14062-24-9

4-chloro-benzeneacetic acid, ethyl ester

Conditions
ConditionsYield
With 1,5-diazabicyclo[5.4.0]-undec-7-ene In N,N-dimethyl-formamide at 0℃;99%
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

4-chlorophenylethylamine
156-41-2

4-chlorophenylethylamine

2-(4-chlorophenyl)-N-[2-(4-chlorophenyl)ethyl]acetamide
325164-96-3

2-(4-chlorophenyl)-N-[2-(4-chlorophenyl)ethyl]acetamide

Conditions
ConditionsYield
In neat (no solvent) at 150℃; for 0.5h; Microwave irradiation;99%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃; for 18h;89%
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

diethyl 5-acetyl-1,6-dihydro-6-oxo-2,3-pyridinedicarboxylate
94746-87-9

diethyl 5-acetyl-1,6-dihydro-6-oxo-2,3-pyridinedicarboxylate

diethyl 3-(p-chlorophenyl)-4-methyl-2-oxo-2H-pyrano[2,3-b]pyridine-6,7-dicarboxylate
111877-27-1

diethyl 3-(p-chlorophenyl)-4-methyl-2-oxo-2H-pyrano[2,3-b]pyridine-6,7-dicarboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane; acetic anhydride99%
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

DIMCARB
4137-10-4

DIMCARB

2-(4-chlorophenyl)-N,N-dimethylacetamide
33297-39-1

2-(4-chlorophenyl)-N,N-dimethylacetamide

Conditions
ConditionsYield
With zirconium(IV) chloride In toluene at 120℃; for 24h; Inert atmosphere; Molecular sieve;99%
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

phenethylamine
64-04-0

phenethylamine

2-(4-chlorophenyl)-N-(2-phenylethyl)acetamide
83303-96-2

2-(4-chlorophenyl)-N-(2-phenylethyl)acetamide

Conditions
ConditionsYield
In neat (no solvent) at 150℃; for 0.5h; Microwave irradiation;99%
4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

2-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]acetamide
340218-64-6

2-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]acetamide

Conditions
ConditionsYield
In neat (no solvent) at 150℃; for 0.5h; Microwave irradiation;99%
p-chlorobenzyl cyanide
140-53-4

p-chlorobenzyl cyanide

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With water; sodium hydroxide at 110 - 116℃; under 15001.5 Torr; for 0.05h; Concentration; Pressure; Temperature; Flow reactor;99%
With 1-butyl-3-methylimidazolium hydrogen sulfate; water at 60 - 65℃; for 1.1h; Green chemistry;96%
With potassium hydroxide In toluene at 160℃; for 0.5h; microwave irradiation;92%
4-chloro-benzeneacetic acid, ethyl ester
14062-24-9

4-chloro-benzeneacetic acid, ethyl ester

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With water; sodium hydroxide In 1,4-dioxane at 60℃; for 2h; pH=10 - 14;98%
carbon monoxide
201230-82-2

carbon monoxide

4-chlorobenzyl bromide
622-95-7

4-chlorobenzyl bromide

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium iodide In formic acid at 60℃; under 760 Torr; for 18h; Carbonylation;95%
With cobalt(II) pyridine-2-carboxylate; palladium diacetate; sodium hydroxide In methanol at 180℃; under 11251.1 Torr; for 6h; Temperature; Reagent/catalyst; Autoclave;95.2%
With palladium hydroxide, 20 wt% on carbon; tetrabutylammomium bromide; water In tetrahydrofuran at 110℃; under 7500.75 Torr; for 4h; Sealed tube; Autoclave;79%
With sodium hydroxide; sodium tetrahydroborate In tetrahydrofuran at 55℃; for 3h;78%
N-[(E)-2-(4-Chloro-phenyl)-1-cyano-vinyl]-4,N-dimethyl-benzamide
89244-19-9, 89244-20-2

N-[(E)-2-(4-Chloro-phenyl)-1-cyano-vinyl]-4,N-dimethyl-benzamide

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran for 6h; Heating;95%
C14H21ClNO3P

C14H21ClNO3P

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With hydrogen bromide at 100℃; for 0.166667h;95%
With water; hydrogen bromide at 100℃; for 0.166667h; Inert atmosphere;95%
4-Methoxybenzyl 2-(4-chlorophenyl)acetate
1575722-27-8

4-Methoxybenzyl 2-(4-chlorophenyl)acetate

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With proton-exchanged montmorillonite In dichloromethane at 20℃;95%
2-(4-chlorophenyl)-1-(pyrrolidin-1-yl)-ethanone
19202-19-8

2-(4-chlorophenyl)-1-(pyrrolidin-1-yl)-ethanone

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane for 30h; Heating;94%
1-Chloro-4-(chloromethyl)benzene
104-83-6

1-Chloro-4-(chloromethyl)benzene

butan-1-ol
71-36-3

butan-1-ol

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
Stage #1: butan-1-ol With cobalt(II) sulfate at 80℃; under 3750.38 Torr; for 4h; Autoclave;
Stage #2: 1-Chloro-4-(chloromethyl)benzene With sodium hydroxide In water at 80℃; under 3750.38 Torr; for 24h; Concentration; Pressure; Temperature; Autoclave;
93.6%
carbon monoxide
201230-82-2

carbon monoxide

1-chloro-4-(dibromomethyl)benzene
62037-06-3

1-chloro-4-(dibromomethyl)benzene

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With potassium hydroxide; dicobalt octacarbonyl; N-benzyl-N,N,N-triethylammonium chloride In benzene under 760 Torr; for 8h; Ambient temperature;92%
(4-chloro-phenyl)-acetic acid methyl ester
52449-43-1

(4-chloro-phenyl)-acetic acid methyl ester

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With sodium hydroxide for 2h; Heating;92%
With potassium hydroxide In methanol for 4h; Ambient temperature;50%
With water for 36h;50%
4-chloro-N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)phenylglycinonitrile

4-chloro-N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)phenylglycinonitrile

A

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

B

N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)amine
888963-33-5

N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)amine

Conditions
ConditionsYield
With hydrogen bromide; acetic acid In dichloromethane; water at 20℃; for 1h;A 92%
B n/a
carbon monoxide
201230-82-2

carbon monoxide

1-Chloro-4-(chloromethyl)benzene
104-83-6

1-Chloro-4-(chloromethyl)benzene

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With cobalt(II) pyridine-2-carboxylate; palladium diacetate; sodium hydroxide In methanol at 180℃; under 11251.1 Torr; for 6h; Temperature; Reagent/catalyst; Solvent; Autoclave;90%
Stage #1: carbon monoxide With C28H22CoN4O6 In butan-1-ol at 60℃; under 760.051 Torr; for 2h; Glovebox; High pressure; Green chemistry;
Stage #2: 1-Chloro-4-(chloromethyl)benzene With tetra-(n-butyl)ammonium iodide; sodium hydroxide In butan-1-ol at 60℃; under 760.051 Torr; for 22h; Glovebox; High pressure; Green chemistry; regioselective reaction;
86%
With bis-triphenylphosphine-palladium(II) chloride; tetraethylammonium chloride; sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene at 80℃; under 11251.1 Torr; for 20h; Autoclave; regioselective reaction;86%
With sodium hydroxide; cerium(III) chloride; cetyltrimethylammonim bromide; nickel cyanide In toluene at 85 - 95℃; under 1 Torr; for 6.5h;82%
With water; palladium diacetate at 110℃; under 37503.8 Torr; for 4h; Ionic liquid;84 %Chromat.
2-(4-chlorophenyl)-1-(morpholin-4-yl)-ethanethione
42945-85-7

2-(4-chlorophenyl)-1-(morpholin-4-yl)-ethanethione

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With sodium hydroxide for 0.0166667h; microwave irradiation;90%
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride at 100℃; for 8h;
1-Chloro-4-(chloromethyl)benzene
104-83-6

1-Chloro-4-(chloromethyl)benzene

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With sodium hydroxide; cobalt tetracarbonyl anion In methanol at 55℃; for 4h;84%
Multi-step reaction with 2 steps
1: dimethylsulfoxide / 5 h / 45 - 50 °C
2: KOH / aq. ethanol / Heating
View Scheme
Multi-step reaction with 2 steps
1: alcohol / 120 - 130 °C / im Druckrohr
2: concentrated KOH-solution
View Scheme
Multi-step reaction with 2 steps
1: alcohol; water
2: concentrated KOH-solution
View Scheme
Multi-step reaction with 2 steps
1: ethanol; H2O / Heating
2: aq. KOH / ethanol / Heating
View Scheme
carbon dioxide
124-38-9

carbon dioxide

(4-chlorobenzylidene)hydrazine
52372-80-2

(4-chlorobenzylidene)hydrazine

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

Conditions
ConditionsYield
With 1,1'-bis-(diphenylphosphino)ferrocene; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; caesium carbonate; cesium fluoride In N,N-dimethyl-formamide at 80℃; under 760.051 Torr; for 24h; chemoselective reaction;82%
4-vinylbenzyl chloride
1073-67-2

4-vinylbenzyl chloride

4-chlorophenylacetic Acid
1878-66-6

4-chlorophenylacetic Acid

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