5-Hydroxy-2-phenylisoindoline-1,3-dione

Base Information

• Chemical Name: 5-Hydroxy-2-phenylisoindoline-1,3-dione
• CAS No.: 3975-50-6
• Molecular Formula: C14H9NO3
• Molecular Weight: 239.23
• DSSTox Substance ID: DTXSID80445430
• Nikkaji Number: J941.734F
• Wikidata: Q82263823
• ChEMBL ID: CHEMBL276030
• Mol file: 3975-50-6.mol

Synonyms:5-hydroxy-2-phenylisoindoline-1,3-dione;4-Hydroxy-N-phenylphthalimide;CHEMBL276030;3975-50-6;5-hydroxy-2-phenyl-isoindole-1,3-dione;D0X6LK;5-HYDROXY-2-PHENYLISOINDOLE-1,3-DIONE;SCHEMBL8615277;DTXSID80445430;HCUAWJNHCZEMJS-UHFFFAOYSA-N;BDBM50088673;PD182603;5-hydroxy-2-phenyl-1H-isoindole-1,3(2H)-dione

Chemical Property of 5-Hydroxy-2-phenylisoindoline-1,3-dione

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 239.058243149
• Heavy Atom Count: 18
• Complexity: 362

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)N2C(=O)C3=C(C2=O)C=C(C=C3)O

Technology Process of 5-Hydroxy-2-phenylisoindoline-1,3-dione

There total 6 articles about 5-Hydroxy-2-phenylisoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-hydroxyphthalic anhydride (27550-59-0) + aniline (62-53-3) → 5-hydroxy-2-phenylisoindoline-1,3-dione (3975-50-6)

Guidance literature:

In toluene; at 110 ℃; for 12h; Molecular sieve; Inert atmosphere;

DOI:10.1021/jm1012165

Reference yield: 84.0%

N-phenyl-maleimide (941-69-5) + 2-(2-Oxo-2H-pyran-4-yloxy)-isoindole-1,3-dione (203728-19-2) → 5-hydroxy-2-phenylisoindoline-1,3-dione (3975-50-6)

Guidance literature:

In toluene; at 205 ℃; for 24h;

DOI:10.1039/a708380g

Reference yield:

4-hydroxyphthalic acid (610-35-5) → 5-hydroxy-2-phenylisoindoline-1,3-dione (3975-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / Heating

2: Heating

DOI:10.1016/j.bmcl.2005.07.048

upstream raw materials:

N-phenyl-maleimide

2-(2-Oxo-2H-pyran-4-yloxy)-isoindole-1,3-dione

4-hydroxyphthalic anhydride

aniline

Downstream raw materials:

trifluoro-methanesulfonic acid 1,3-dioxo-2-phenyl-2,3-dihydro-1H-isoindol-5-yl ester

2-phenylisoindole-1,3-dion-5-yl (E)-3-(4-nitrophenyl)acrylat

C₂₉H₂₂ClNO₄

4-chloro-3'-((1-oxo-2-phenylisoindolin-5-yloxy)methyl)biphenyl-3-carboxylic acid