2-Chloro-6-methylnicotinoylchloride

Base Information

• Chemical Name: 2-Chloro-6-methylnicotinoylchloride
• CAS No.: 39853-81-1
• Molecular Formula: C7H5Cl2NO
• Molecular Weight: 190.02700
• Hs Code.: 2933399090
• Mol file: 39853-81-1.mol

Synonyms:6-methyl-2-chloronicotinoyl chloride;2-chloro-6-methylnictotinyl chloride;2-Chlor-6-methylpyridin-3-carbonsaeurechlorid;QC-1505;2-chloro-6-methyl-nicotinic acid chloride;2-Chloro-6-methylnicotinoylchloride;

Chemical Property of 2-Chloro-6-methylnicotinoylchloride

Chemical Property:

• Vapor Pressure: 0.00462mmHg at 25°C
• Refractive Index: 1.5715
• Boiling Point: 277.1oC at 760 mmHg
• PKA: -1.03±0.10(Predicted)
• Flash Point: 121.4oC
• PSA: 29.96000
• Density: 1.384g/cm3
• LogP: 2.42240
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-6-methylnicotinoyl chloride 97% ^*data from reagent suppliers

Safty Information:

• Statements: 34
• Safety Statements: 20-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-6-methylnicotinoylchloride

There total 3 articles about 2-Chloro-6-methylnicotinoylchloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-6-methyl nicotinic acid (30529-70-5) → 2-chloro-6-methyl-nicotinic acid chloride (39853-81-1)

Guidance literature:

With trichlorophosphate; for 2h; Heating;

DOI:10.1039/b417485b

Reference yield:

2-hydroxy-6-methylnicotinic acid (38116-61-9) → 2-chloro-6-methyl-nicotinic acid chloride (39853-81-1)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; for 3h; Heating;

DOI:10.1021/jm00114a007

Reference yield:

→ 2-chloro-6-methyl-nicotinic acid chloride (39853-81-1)

Guidance literature:

2-Chlor-6-methylpyridin-3-carbonsaeure (II), PCl5;

DOI:10.1007/BF00471881

upstream raw materials:

2-hydroxy-6-methylnicotinic acid

2-chloro-6-methyl nicotinic acid

Downstream raw materials:

2-chloro-6-methyl-3-pyridinecarboxamide

2-chloro-6-methylnicotinic acid methyl ester

N-Ethyl-6-methyl-2-phenylamino-nicotinamide

6,N-Dimethyl-2-p-tolylamino-nicotinamide