Chemical Property of Estetrol
Chemical Property:
- Melting Point:233-236°C
- Refractive Index:1.65
- Boiling Point:491.9 °C at 760 mmHg
- PKA:10.22±0.70(Predicted)
- Flash Point:231.7 °C
- PSA：80.92000
- Density:1.343 g/cm3
- LogP:1.55080
- Storage Temp.:-20?C Freezer
- Solubility.:DMSO: soluble20mg/mL, clear
- XLogP3:1.5
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:0
- Exact Mass:304.16745924
- Heavy Atom Count:22
- Complexity:441
- Purity/Quality:
-
99% *data from raw suppliers
Estetrol *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC12CCC3C(C1C(C(C2O)O)O)CCC4=C3C=CC(=C4)O
- Isomeric SMILES:C[C@]12CC[C@H]3[C@H]([C@@H]1[C@H]([C@H]([C@@H]2O)O)O)CCC4=C3C=CC(=C4)O
- Recent ClinicalTrials:Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women
- Recent EU Clinical Trials:A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 2 STUDY TO ASSESS THE INFLUENCE OF ESTETROL (E4) ON SKIN PARAMETERS IN POSTMENOPAUSAL WOMEN (PILOT STUDY)
- Recent NIPH Clinical Trials:Phase II study to evaluate pharmacodynamics, pharmacokinetics and safety after cyclic dose or continuous dose of FSN-013 for 3 cycles in Japanese healthy adult female subjects
-
Uses
Estetrol is an estrogen steroid hormone exclusively produced by fetal liver from estradiol and estriol during pregnancy. It binds to estrogen receptors (ERs) with 4-fold higher affinity for ERα over ERβ and exhibits estrogenic effects in most tissues expressing ERs (bone, brain, vagina, and endometrium). In breast tumors, however, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth. A metabolite of Estradiol. It is an estrogenic steroid synthesized exclusively by the fetal liver during human pregnancy and reaching the maternal circulation through the placenta.
