N-(3-chlorophenyl)furan-2-carboxamide

Base Information

• Chemical Name: N-(3-chlorophenyl)furan-2-carboxamide
• CAS No.: 2008-49-3
• Molecular Formula: C11H8 Cl N O2
• Molecular Weight: 221.6397
• NSC Number: 136405
• DSSTox Substance ID: DTXSID30942106
• Nikkaji Number: J1.144.554C
• Wikidata: Q82919080
• ChEMBL ID: CHEMBL558061
• Mol file: 2008-49-3.mol

Synonyms:N-(3-chlorophenyl)furan-2-carboxamide;2008-49-3;CHEMBL558061;2-Furancarboxamide, N-(3-chlorophenyl)-;n-(3-chlorophenyl)-2-furamide;NSC136405;N-(3-Chlorophenyl)-2-furancarboxamide;SCHEMBL5115718;DTXSID30942106;GXPIOIIKCASZKA-UHFFFAOYSA-N;BDBM50293736;STK873810;AKOS001569463;NSC-136405;SR-01000392716;SR-01000392716-1;Z28141046

Chemical Property of N-(3-chlorophenyl)furan-2-carboxamide

Chemical Property:

• Vapor Pressure: 0.0254mmHg at 25°C
• Boiling Point: 247.6°Cat760mmHg
• Flash Point: 103.5°C
• Density: 1.359g/cm³
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 221.0243562
• Heavy Atom Count: 15
• Complexity: 235

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)Cl)NC(=O)C2=CC=CO2

Technology Process of N-(3-chlorophenyl)furan-2-carboxamide

There total 5 articles about N-(3-chlorophenyl)furan-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-chloro-aniline (108-42-9) + 2-furanoyl sulfonate (1026046-13-8) → N-(3-Chlorophenyl)-2-furancarboxamide (2008-49-3)

Guidance literature:

With PEG-400; potassium carbonate; In acetonitrile; for 0.25h; Heating;

DOI:10.1080/00397919908086466

Reference yield:

2-furancarbonyl chloride (527-69-5) + 3-chloro-aniline (108-42-9) → N-(3-Chlorophenyl)-2-furancarboxamide (2008-49-3)

Guidance literature:

With pyridine;

Reference yield:

2-furanoic acid (88-14-2) → N-(3-Chlorophenyl)-2-furancarboxamide (2008-49-3)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 0.5 h / Heating

2: triethylamine / CH₂Cl₂ / 1 h / Heating

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1002/jhet.5570390616

upstream raw materials:

2-furancarbonyl chloride

3-chloro-aniline

2-(tributylstannyl)furan

m-chlorophenyl isocyanate