(6-(Bromomethyl)pyridin-2-yl)methanol

Base Information

• Chemical Name: (6-(Bromomethyl)pyridin-2-yl)methanol
• CAS No.: 40054-01-1
• Molecular Formula: C7H8BrNO
• Molecular Weight: 202.051
• Hs Code.: 2933399090
• European Community (EC) Number: 678-043-5
• DSSTox Substance ID: DTXSID30446816
• Nikkaji Number: J790.176C
• Wikidata: Q82265538
• Mol file: 40054-01-1.mol

Synonyms:40054-01-1;(6-(Bromomethyl)pyridin-2-yl)methanol;2-(Bromomethyl)-6-(hydroxymethyl)pyridine;[6-(bromomethyl)pyridin-2-yl]methanol;6-bromomethyl-2-pyridinemethanol;6-(Bromomethyl)-2-pyridinemethanol;2-Pyridinemethanol, 6-(bromomethyl)-;SCHEMBL243652;3-Cyano-4-fluorophenylaceticacid;DTXSID30446816;JLYYQZROGJLCCS-UHFFFAOYSA-N;2-bromomethyl-6-hydroxymethylpyridine;MFCD01631297;AKOS015967533;SB21190;AS-40776;B1963;CS-0452216;FT-0700773;(6-BROMOMETHYL-PYRIDIN-2-YL)METHANOL;EN300-196483;A873498

Chemical Property of (6-(Bromomethyl)pyridin-2-yl)methanol

Chemical Property:

• Vapor Pressure: 0.00143mmHg at 25°C
• Melting Point: 80 °C
• Refractive Index: 1.606
• Boiling Point: 284.122 °C at 760 mmHg
• Flash Point: 125.633 °C
• PSA: 33.12000
• Density: 1.604 g/cm³
• LogP: 1.46880
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 200.97893
• Heavy Atom Count: 10
• Complexity: 99.6

Purity/Quality:

97% ^*data from raw suppliers

6-(Bromomethyl)-2-pyridinemethanol ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1)CBr)CO

Technology Process of (6-(Bromomethyl)pyridin-2-yl)methanol

There total 1 articles about (6-(Bromomethyl)pyridin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2.6-bis(hydroxymethyl)pyridine (1195-59-1) → 2,6-bis-(bromomethyl)pyridine (7703-74-4) + (6-(bromomethyl)pyridin-2-yl)methanol (40054-01-1)

Guidance literature:

With hydrogen bromide; for 15h; Heating;

DOI:10.1002/1099-0682(200212)2002:12<3284::AID-EJIC3284>3.0.CO;2-6

Reference yield: 94.0%

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) + (6-(bromomethyl)pyridin-2-yl)methanol (40054-01-1) → 2-((6-(hydroxymethyl)pyridin-2-yl)methoxy)-4-methoxybenzaldehyde

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield: 94.0%

2-(3-hydroxy-6-methoxy-9H-xanthene-9-yl)benzoic acid methyl ester (1374021-44-9) + (6-(bromomethyl)pyridin-2-yl)methanol (40054-01-1) → 2-[3-(2-hydroxymethyl-6-pyridylmethoxy)-6-methoxy-9H-xanthen-9-yl]benzoic acid methyl ester (1225014-61-8)

Guidance literature:

With potassium carbonate; In acetonitrile; Inert atmosphere; Reflux;

DOI:10.1021/ja100714p

upstream raw materials:

2.6-bis(hydroxymethyl)pyridine

Downstream raw materials:

1,9-bis<6-(hydroxymethyl)pyridin-2-yl>-2,5,8-tritosyl-2,5,8-triazanonane

1,11-bis<6-(hydroxymethyl)pyridin-2-yl>-2,6,10-tritosyl-2,6,10-triazaundecane

2,6-bis<methyl>-N-tosylamino>methyl>pyridine

{6-[3-(6-Hydroxymethyl-pyridin-2-ylmethylsulfanylmethyl)-benzylsulfanylmethyl]-pyridin-2-yl}-methanol