2-Amino-3-bromo-5-nitrobenzotrifluoride 95+%

Base Information

• Chemical Name: 2-Amino-3-bromo-5-nitrobenzotrifluoride 95+%
• CAS No.: 400-66-8
• Molecular Formula: C7H4BrF3N2O2
• Molecular Weight: 285.02
• Hs Code.: 2921420090
• Mol file: 400-66-8.mol

Synonyms:2-Brom-4-nitro-6-trifluormethyl-anilin;Benzenamine,2-bromo-4-nitro-6-(trifluoromethyl);2-bromo-4-nitro-6-trifluoromethylaniline;2-bromo-4-nitro-6-trifluoromethyl-phenylamine;

Chemical Property of 2-Amino-3-bromo-5-nitrobenzotrifluoride 95+%

Chemical Property:

• Melting Point: 140-142 °C
• Boiling Point: 306.8±37.0 °C(Predicted)
• PKA: -4.03±0.46(Predicted)
• PSA: 71.84000
• Density: 1.859±0.06 g/cm3(Predicted)
• LogP: 4.06270

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-4-nitro-6-(trifluoromethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-3-bromo-5-nitrobenzotrifluoride 95+%

There total 1 articles about 2-Amino-3-bromo-5-nitrobenzotrifluoride 95+% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

4-nitro-2-trifluoromethyl-aniline (121-01-7) → 2-bromo-4-nitro-6-trifluoromethylaniline (400-66-8)

Guidance literature:

4-nitro-2-trifluoromethyl-aniline; With hydrogen bromide; at 20 - 70 ℃; for 0.166667h;

With dihydrogen peroxide; In water; at 60 - 70 ℃; for 3h;

DOI:10.3184/174751913X13619014318618

Reference yield: 56.0%

2-bromo-4-nitro-6-trifluoromethylaniline (400-66-8) + acetic anhydride (108-24-7) → 2-Bromo-4-nitro-6-(trifluoromethyl)acetanilide (85977-20-4)

Guidance literature:

With zinc(II) chloride; In benzene; for 32h; Heating;

DOI:10.1021/jo00162a005

Reference yield: 33.0%

2-bromo-4-nitro-6-trifluoromethylaniline (400-66-8) + 3-cyclohexylpropionyl chloride (39098-75-4) → N-(2-bromo-4-nitro-6-trifluoromethyl-phenyl)-3-cyclohexyl-propionamide (879644-51-6)

Guidance literature:

In acetonitrile; at 150 ℃; for 0.166667h; Microwave irradiation;

upstream raw materials:

4-nitro-2-trifluoromethyl-aniline

Downstream raw materials:

(2-Bromo-4-nitro-6-trifluoromethyl-phenyl)-(2,4-dinitro-naphthalen-1-yl)-amine

2-Bromo-4-nitro-6-(trifluoromethyl)acetanilide

1-Bromo-2-iodo-3-(trifluoromethyl)benzene

2-bromo-6-trifluoromethylphenylamine

Refernces

• 1、 -. "SUBSTITUTED ANILINE DERIVATIVES". Page/Page column 58. . Retrieved 2008/06/13.
• 2、 Grunewald, Gary L.,Paradkar, Vidyadhar M.,Pazhenchevsky, Bharak,Pleiss, Michael A.,Sall, Daniel J.,et al.. "Synthesis of Conformationally Defined Analogues of Norfenfluramine. A Highly Stereospecific Synthesis of Amines from Alcohols in the Benzobicycloheptene System". . p. 2321 - 2327. Retrieved 2007/10/02.