85977-20-4

Basic information

• Product Name: 2-Bromo-4-nitro-6-(trifluoromethyl)acetanilide
• Synonyms: 2-Bromo-4-nitro-6-(trifluoromethyl)acetanilide
• CAS NO: 85977-20-4
• Molecular Weight: 327.057
• Mol File: 85977-20-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Bromo-4-nitro-6-(trifluoromethyl)acetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-nitro-6-(trifluoromethyl)acetanilide(85977-20-4)
• EPA Substance Registry System: 2-Bromo-4-nitro-6-(trifluoromethyl)acetanilide(85977-20-4)

Safety Data

• Hazardous Substances Data: 85977-20-4(Hazardous Substances Data)

Upstream product

• 400-66-8 2-bromo-4-nitro-6-trifluoromethylaniline 
• 121-01-7 4-nitro-2-trifluoromethyl-aniline 
• 108-24-7 acetic anhydride 

Downstream Products

• 85977-22-6 N-(2-bromo-6-(trifluoromethyl)phenyl)acetamide 
• 58458-13-2 2-bromo-6-trifluoromethylphenylamine 
• 85977-23-7 1-Bromo-2-iodo-3-(trifluoromethyl)benzene 
• 85977-21-5 2-Bromo-4-amino-6-(trifluoromethyl)acetanilide 

Relevant articles and documents

Synthesis of Conformationally Defined Analogues of Norfenfluramine. A Highly Stereospecific Synthesis of Amines from Alcohols in the Benzobicycloheptene System

The synthesis of 5-, 6-, 7-, and 8-(trifluoromethyl)benzonorbornen-2-yl alcohols 6a-9a (exo) and 11a-14a (endo) and an examination of the stereospecificity of the conversion to amines via phthalimides are reported.The exo alcohols were prepared from 5-(trifluoromethyl)benzonorbornadiene (16) and 6-(trifluoromethyl)benzonorbornadiene (23) by hydroboration-oxidation.The endo alcohols were available from the corresponding exo alcohols by oxidation to the benzonorbornen-2-ones 24 (5-CF3), 25 (6-CF3), 26 (7-CF3), and 27 (8-CF3) followed by diborane reduction.While in the presence of the electron-withdrawing CF3 group the exo alcohols gave predominantly the endo amines, the endo alcohols afforded exclusively the exo amines.