6,7-Dimethoxy-4-methylquinazoline

Base Information

• Chemical Name: 6,7-Dimethoxy-4-methylquinazoline
• CAS No.: 4015-31-0
• Molecular Formula: C11H12N2O2
• Molecular Weight: 204.228
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID50401881
• Wikidata: Q82205160
• Mol file: 4015-31-0.mol

Synonyms:6,7-dimethoxy-4-methylquinazoline;4015-31-0;4-Methyl-6,7-dimethoxyquinazoline;SCHEMBL1260737;DTXSID50401881;IVRQVBUDDJNGRF-UHFFFAOYSA-N;EN300-9443030

Chemical Property of 6,7-Dimethoxy-4-methylquinazoline

Chemical Property:

• Vapor Pressure: 0.000342mmHg at 25°C
• Boiling Point: 329.4oC at 760 mmHg
• Flash Point: 120.6oC
• PSA: 44.24000
• Density: 1.171g/cm3
• LogP: 1.95540
• Storage Temp.: 2-8°C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 204.089877630
• Heavy Atom Count: 15
• Complexity: 213

Purity/Quality:

95% ^*data from raw suppliers

6,7-Dimethoxy-4-methylquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=NC2=CC(=C(C=C12)OC)OC

Technology Process of 6,7-Dimethoxy-4-methylquinazoline

There total 2 articles about 6,7-Dimethoxy-4-methylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-amino-4,5-dimethoxyacetophenone (4101-30-8) + formamide (77287-34-4,77287-35-5,60100-09-6) → 4-methyl-6,7-dimethoxyquinazoline (4015-31-0)

Guidance literature:

boron trifluoride diethyl etherate; at 130 - 135 ℃; for 2h;

Reference yield:

2-amino-4,5-dimethoxyacetophenone (4101-30-8) → 4-methyl-6,7-dimethoxyquinazoline (4015-31-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Ambient temperature; overnight

2: 82 percent / ethanolic ammonia / ethanol / 17 h / 140 °C / stainless steel bomb

With ammonia; In ethanol;

DOI:10.1002/jhet.5570170726

Reference yield:

4-methyl-6,7-dimethoxyquinazoline (4015-31-0) → 4-<(1,3-dioxocyclohex-2-yl)ethyl>-6,7-dimethoxyquinazoline (76787-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / ethanol / 22 h / in dark

2: 36 percent / potassium t-butoxide / 2-methyl-propan-2-ol / 43 h / Heating

With potassium tert-butylate; In ethanol; tert-butyl alcohol;

DOI:10.1002/jhet.5570170726

upstream raw materials:

2-amino-4,5-dimethoxyacetophenone

formamide

Downstream raw materials:

4-<(1,3-dioxocyclohex-2-yl)ethyl>-6,7-dimethoxyquinazoline

Refernces

• 1、 Malecki, Natacha,Carato, Pascal,Rigo, Benoit,Goossens, Jean-Francois,Houssin, Raymond,Bailly, Christian,Henichart, Jean-Pierre. "Synthesis of condensed quinolines and quinazolines as DNA ligands". . p. 641 - 647. Retrieved 2007/10/03.
• 2、 Phillips,Castle. "Quino[1,2-c]quinazolines. I. Synthesis of quino[1,2-c]quinazolinium derivatives and the related indazolo[2,3-a]quinoline derivatives as analogs of the antitumor benzo[c]phenanthridine alkaloids". . p. 1489 - 1495. Retrieved 2007/10/02.