4101-30-8

Basic information

• Product Name: 2'-AMINO-4',5'-DIMETHOXYACETOPHENONE
• Synonyms: 2'-Amino-4',5'-dimethoxyacetophenone;2'-AMINO-4',5'-DIMETHOXYACETOPHENONE;2-AMINO-4,5-DIMETHOXYACETOPHENONE;1-(2-AMINO-4,5-DIMETHOXYHENYL) ETHANONE;1-(2-AMINO-4,5-DIMETHOXY-PHENYL)-ETHANONE;LABOTEST-BB LT00080708;4',5'-Dimethoxy-2'-aminoacetophenone;1-(2-aMino-4,5-diMethoxyphenyl)ethan-1-one
• CAS NO: 4101-30-8
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.22
• Product Categories: Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 4101-30-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 106-108°C
• Boiling Point: 343.5 °C at 760 mmHg
• Flash Point: 172.2 °C
• Appearance: /
• Density: 1.139
• Solubility: soluble in Methanol
• PKA: 2.48±0.10(Predicted)
• BRN: 391380
• CAS DataBase Reference: 2'-AMINO-4',5'-DIMETHOXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-AMINO-4',5'-DIMETHOXYACETOPHENONE(4101-30-8)
• EPA Substance Registry System: 2'-AMINO-4',5'-DIMETHOXYACETOPHENONE(4101-30-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 4101-30-8(Hazardous Substances Data)

Usage

Uses

2''-Amino-4'',5''-Dimethoxyacetophenone is a bird repellant.

Upstream product

• 4101-32-0 4',5'-dimethoxy-2'-nitroacetophenone 
• 64-19-7 acetic acid 
• 67-64-1 acetone 
• 7647-01-0 hydrogenchloride 
• 881-70-9 3',4'-dimethoxyacetanilide 
• 26961-27-3 2-amino-4,5-dimethoxybenzonitrile 
• 6315-89-5 3,4-dimethoxyaniline 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 91-16-7 1,2-dimethoxybenzene 

Downstream Products

• 148842-95-9 acetic acid-(2-acetyl-4,5-dimethoxy-anilide) 
• 91246-62-7 4,5-dimethoxy-2-(1-methylethenyl)benzenamine 
• 91340-86-2 2-(2-Amino-4,5-dimethoxy-phenyl)-propan-2-ol 
• 3358-09-6 Ethylxanthogensaeure-(4,5-dimethoxy-2-acetyl-phenylester) 
• 3358-11-0 3,4-Dimethoxy-6-thiocyanato-acetophenon 
• 98300-43-7 ethyl N-(6-acetyl-3,4-dimethoxyphenyl)-4-aminobutyrate 
• 98300-44-8 ethyl N-(6-acetyl-3,4-dimethoxyphenyl)-5-aminopentanoate 
• 86201-75-4 4,5-dimethoxy-2-selenocyanatoacetophenone 
• 156785-66-9 4,5-dimethoxy-2-<(4-methoxybenzoyl)amino>acetophenone 
• 4015-31-0 4-methyl-6,7-dimethoxyquinazoline 
• 156785-68-1 2-<(3,5-dimethoxybenzoyl)amino>-4,5-dimethoxyacetophenone 
• 139439-33-1 N-(2-Acetyl-4,5-dimethoxy-phenyl)-2,2,2-trifluoro-acetamide 
• 4101-29-5 N-(2-acetyl-4,5-dimethoxyphenyl)formamide 
• 87364-95-2 methyl 3--propionate 

Relevant articles and documents

Experimental and Computational Studies on Cp*CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings for Building Eight-Membered Sultam/Lactam Frameworks

Described herein is an unusual Cp*CyRh(III)-catalyzed intramolecular site-specific aryl C-H annulation, a highly chemoselective protocol providing direct access to eight-membered sultams/lactams with broad substrate/functional group tolerance. Experimental and computational studies reveal that such a transformation involves a unique PivOH-assisted aryl C-H activation/alkene insertion/β-H elimination/hydrogen-transfer process involving the Rh(III)-hydride species as the active intermediate with the concomitant release of H2 as the major byproduct, thus enabling the developed Cp*CyRh(III) catalysis with redox-neutral and highly atom-economical features.

EGFR INHIBITOR, AND PREPARATION AND APPLICATION THEREOF

A 4-substituted-2-(N-(5-substituted allyl amide)phenyl)amino)pyrimidine derivative as represented by formula (I), and a preparation and application thereof as an EGFR inhibitor. The compound has activity of inhibiting the L858R EGFR mutant, the T790M EGFR mutant and the exon 19 deletion activating mutant, may be used to treat diseases mediated alone or in part by EGFR mutant activity, and has a wide application in drugs preventing and treating cancers, particularly non-small cell lung cancer.

A new general approach to 4-substituted-3-halo-2-quinolones

A general procedure for the preparation of 4-substituted-3-halo-2-quinolones (halo = F, Cl, Br) utilizing 2-halo diethylphosphonoacetic acids (halo = F, Cl, Br) and o-aminophenylketones as the starting materials is described. The title compounds are obtained by an intramolecular Horner-Wadsworth-Emmons olefination of halogen-containing N-acyl-o-aminophenylketones. The transformation process is generally applicable under mild conditions.