1-Pyrrolidinecarboxylic acid, 4-[(4-cyanobenzoyl)amino]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4S)-

Base Information

• Chemical Name: 1-Pyrrolidinecarboxylic acid, 4-[(4-cyanobenzoyl)amino]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4S)-
• CAS No.: 401565-49-9
• Molecular Formula: C21H26N4O4S
• Molecular Weight: 430.528
• Mol file: 401565-49-9.mol

Synonyms:

Chemical Property of 1-Pyrrolidinecarboxylic acid, 4-[(4-cyanobenzoyl)amino]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4S)-

Chemical Property:

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Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 4-[(4-cyanobenzoyl)amino]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4S)-

There total 2 articles about 1-Pyrrolidinecarboxylic acid, 4-[(4-cyanobenzoyl)amino]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-((2S,4S)-4-amino-1-tert-butoxycarbonyl-2-pyrrolidinylcarbonyl)-1,3-thiazolidine (401564-31-6) + 4-cyanobenzoyl chlorIde (6068-72-0) → 3-[(2S,4S)-1-tert-butoxycarbonyl-4-(4-cyanobenzoyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine (401565-49-9)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2006.10.059

Reference yield:

(2S,4S)-4-benzoylamino-1-tert-butoxycarbonylpyrrolidine-2-carboxylic acid (401564-27-0) + 4-cyanobenzoyl chlorIde (6068-72-0) → 3-[(2S,4S)-1-tert-butoxycarbonyl-4-(4-cyanobenzoyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine (401565-49-9)

Guidance literature:

Reference yield: 67.0%

3-[(2S,4S)-1-tert-butoxycarbonyl-4-(4-cyanobenzoyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine (401565-49-9) → 3-[(2S,4S)-4-(4-cyanobenzoyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine hydrochloride

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 19h;

DOI:10.1016/j.bmc.2006.10.059

upstream raw materials:

3-((2S,4S)-4-amino-1-tert-butoxycarbonyl-2-pyrrolidinylcarbonyl)-1,3-thiazolidine

4-cyanobenzoyl chlorIde

(2S,4S)-4-benzoylamino-1-tert-butoxycarbonylpyrrolidine-2-carboxylic acid

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