401564-27-0Relevant academic research and scientific papers
Disulfide-Bridged Peptides That Mediate Enantioselective Cycloadditions through Thiyl Radical Catalysis
Ryss, Jonathan M.,Turek, Amanda K.,Miller, Scott J.
supporting information, p. 1621 - 1625 (2018/03/23)
An enantioselective vinylcyclopropane ring-opening/cycloaddition cascade is described. The active thiyl radical catalysts are generated in situ via UV light-promoted homolysis of cystine-based dimers. Amide-functionalization of the peptide at the 4-proline position is essential for effective asymmetric induction. Stereochemical communication is dependent on steric interactions with this substituent that are enforced by H-bonding to the peptide backbone.
Properties and structure-activity studies of cyclic β-hairpin peptidomimetics based on the cationic antimicrobial peptide protegrin I
Robinson, John A.,Shankaramma, Sasalu C.,Jetter, Peter,Kienzl, Ursula,Schwendener, Reto A.,Vrijbloed, Jan W.,Obrecht, Daniel
, p. 2055 - 2064 (2007/10/03)
The properties and structure-activity relationships (SAR) of a macrocyclic analogue of porcine protegrin I (PG-I) have been investigated. The lead compound, having the sequence cyclo-(-Leu-Arg-Leu-Lys-Lys-Arg-Arg-Trp-Lys-Tyr- Arg-Val-d-Pro-Pro-), shows an
PROLINE DERIVATIVES AND USE THEREOF AS DRUGS
-
, (2008/06/13)
The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.
