1-Pyrrolidinecarboxylic acid, 3,4-dihydroxy-2-(hydroxymethyl)-5-[4-methoxy-5-[(phenylmethoxy)methyl ]-5H-pyrrolo[3,2-d]pyrimidin-7-yl]-, 1,1-dimethylethyl ester, (2R,3R,4S,5S)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 3,4-dihydroxy-2-(hydroxymethyl)-5-[4-methoxy-5-[(phenylmethoxy)methyl ]-5H-pyrrolo[3,2-d]pyrimidin-7-yl]-, 1,1-dimethylethyl ester, (2R,3R,4S,5S)-
CAS No.:402477-37-6
Molecular Formula:C25H32N4O7
Molecular Weight:500.552
Hs Code.:
Mol file:402477-37-6.mol

1-Pyrrolidinecarboxylic acid,
3,4-dihydroxy-2-(hydroxymethyl)-5-[4-methoxy-5-[(phenylmethoxy)methyl
]-5H-pyrrolo[3,2-d]pyrimidin-7-yl]-, 1,1-dimethylethyl ester,
(2R,3R,4S,5S)-

Synonyms:

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 3,4-dihydroxy-2-(hydroxymethyl)-5-[4-methoxy-5-[(phenylmethoxy)methyl ]-5H-pyrrolo[3,2-d]pyrimidin-7-yl]-, 1,1-dimethylethyl ester, (2R,3R,4S,5S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Pyrrolidinecarboxylic acid, 3,4-dihydroxy-2-(hydroxymethyl)-5-[4-methoxy-5-[(phenylmethoxy)methyl ]-5H-pyrrolo[3,2-d]pyrimidin-7-yl]-, 1,1-dimethylethyl ester, (2R,3R,4S,5S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 3,4-dihydroxy-2-(hydroxymethyl)-5-[4-methoxy-5-[(phenylmethoxy)methyl ]-5H-pyrrolo[3,2-d]pyrimidin-7-yl]-, 1,1-dimethylethyl ester, (2R,3R,4S,5S)-

There total 20 articles about 1-Pyrrolidinecarboxylic acid, 3,4-dihydroxy-2-(hydroxymethyl)-5-[4-methoxy-5-[(phenylmethoxy)methyl ]-5H-pyrrolo[3,2-d]pyrimidin-7-yl]-, 1,1-dimethylethyl ester, (2R,3R,4S,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 364046-18-4
1S-5-O-tert-butyldimethylsilyl-1,4-dideoxy-1-C-[(4-methyoxypyrrolo[3,2-d]pyrimidin-9-N-(benzyloxomethyl)-7-yl)]-1,4-imino-2,3-O-isopropylidine-D-ribitol

: 402477-37-6
(2S,3S,4R,5R)-tert-butyl 2-(5-(benzyloxymethyl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: aq. TFA / tetrahydrofuran / 1.5 h / Heating

2: 2.28 g / Et₃N / methanol / 1 h

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol;
DOI:10.1021/jm030145r

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 2-(5-benzyloxymethyl-4-methoxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-hydroxymethyl-pyrrolidine-3,4-diol

: 402477-37-6
(2S,3S,4R,5R)-tert-butyl 2-(5-(benzyloxymethyl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: With triethylamine; In methanol; for 1h;
DOI:10.1021/jm030145r

Reference yield:

: 1044813-00-4
5-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-L-lyxonic acid-1,4-lactone

: 402477-37-6
(2S,3S,4R,5R)-tert-butyl 2-(5-(benzyloxymethyl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 22 h / -5 - 20 °C

2.1: pyridine; dmap / 4 h / 0 - 20 °C / Inert atmosphere

3.1: 48 h / 70 °C

4.1: hydrogen; palladium on activated charcoal / ethanol / 5 h / 4137.29 Torr

5.1: N-chloro-succinimide / toluene / 17 - 23 °C

5.2: 17 h / -5 - 5 °C

6.1: n-butyllithium / diethyl ether; hexane / 1.2 h / -70 - -50 °C / Inert atmosphere

6.2: 0.25 h / -50 - -2 °C

7.1: dichloromethane / 0.5 h / 5 - 10 °C

8.1: water; hydrogenchloride / methanol / 25 h / 20 - 35 °C

With pyridine; hydrogenchloride; methanol; dmap; sodium tetrahydroborate; N-chloro-succinimide; n-butyllithium; palladium on activated charcoal; water; hydrogen; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; toluene;