Propanedioic acid, methyl(2-phenoxy-2-propenyl)-, dimethyl ester

Base Information

Chemical Name:Propanedioic acid, methyl(2-phenoxy-2-propenyl)-, dimethyl ester
CAS No.:403855-58-3
Molecular Formula:C15H18O5
Molecular Weight:278.305
Hs Code.:
DSSTox Substance ID:DTXSID80478440
Nikkaji Number:J1.833.507G
Wikidata:Q82311825
Mol file:403855-58-3.mol

Synonyms:403855-58-3;Propanedioic acid, methyl(2-phenoxy-2-propenyl)-, dimethyl ester;DTXSID80478440

Suppliers and Price of Propanedioic acid, methyl(2-phenoxy-2-propenyl)-, dimethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanedioic acid, methyl(2-phenoxy-2-propenyl)-, dimethyl ester

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:278.11542367
Heavy Atom Count:20
Complexity:353

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC(=C)OC1=CC=CC=C1)(C(=O)OC)C(=O)OC

Technology Process of Propanedioic acid, methyl(2-phenoxy-2-propenyl)-, dimethyl ester

There total 8 articles about Propanedioic acid, methyl(2-phenoxy-2-propenyl)-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 63915-88-8
1-acetoxy-2-bromo-2-propene

: 609-02-9
methyl-malonic acid dimethylester

: 108-95-2,27073-41-2
phenol

: 199923-58-5
methyl 4-bromo-2-(methylcarboxy)-2-methylpent-4-enoate

: 403855-58-3
methyl 2-(methylcarboxy)-2-methyl-4-phenoxypent-4-enoate

: 2-methyl-2-(1-phenoxymethyl-vinyl)-malonic acid dimethyl ester

: (E)-tetramethyl 3-methylenehexane-2,2,5,5-tetracarboxylate

Guidance literature:: methyl-malonic acid dimethylester; phenol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.166667h;

1-acetoxy-2-bromo-2-propene; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1021/jo034119c

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 403855-58-3
methyl 2-(methylcarboxy)-2-methyl-4-phenoxypent-4-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: (PPh₃)4Pd; CsF / tetrahydrofuran / 65 °C

2.1: NaH / tetrahydrofuran / 0.08 h

2.2: 85 percent / (PPh₃)4Pd / tetrahydrofuran / 17 h / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; cesium fluoride; In tetrahydrofuran; 1.1: Suzuki coupling;
DOI:10.1021/ja011508k

Reference yield:

: 108-95-2,27073-41-2
phenol

: 403855-58-3
methyl 2-(methylcarboxy)-2-methyl-4-phenoxypent-4-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran

1.2: 100 percent / (PPh₃)4Pd / tetrahydrofuran / Heating

2.1: NaH / tetrahydrofuran / 0.08 h

2.2: 85 percent / (PPh₃)4Pd / tetrahydrofuran / 17 h / 60 °C

With sodium hydride; In tetrahydrofuran;
DOI:10.1021/ja011508k