2,3-DIHYDRO-6-METHOXY-3-OXO-1H-INDENE-1-CARBOXYLIC ACID

Base Information

• Chemical Name: 2,3-DIHYDRO-6-METHOXY-3-OXO-1H-INDENE-1-CARBOXYLIC ACID
• CAS No.: 17825-44-4
• Molecular Formula: C11H10O4
• Molecular Weight: 206.19
• Hs Code.: 2918990090
• Mol file: 17825-44-4.mol

Synonyms:6-Methoxy-3-oxo-indan-1-carbonsaeure;6-Methoxy-3-oxo-2,3-dihydro-1H-indene-1-carboxylic acid;3-Carboxy-5-methoxy-indanon;6-methoxy-3-oxo-indan-1-carboxylic acid;1H-Indene-1-carboxylic acid,2,3-dihydro-6-methoxy-3-oxo;6-Methoxyindan-3-on-1-carbonsaeure;2,3-Dihydro-6-Methoxy-3-Oxo-1H-Indene-1-Carboxylic Acid;6-methoxy-2,3-dihydro-inden-3-keto-1-carboxylic acid;

Chemical Property of 2,3-DIHYDRO-6-METHOXY-3-OXO-1H-INDENE-1-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.29E-07mmHg at 25°C
• Boiling Point: 414.6°C at 760 mmHg
• Flash Point: 168.5°C
• PSA: 63.60000
• Density: 1.363g/cm³
• LogP: 1.44980
• Storage Temp.: 2-8°C

Purity/Quality:

≥99% ^*data from raw suppliers

6-methoxy-3-oxo-2,3-dihydro-1H-indene-1-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-DIHYDRO-6-METHOXY-3-OXO-1H-INDENE-1-CARBOXYLIC ACID

There total 5 articles about 2,3-DIHYDRO-6-METHOXY-3-OXO-1H-INDENE-1-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-(3-Methoxyphenyl)succinic acid (15378-02-6) → 3-Carboxy-5-methoxy-indanon (17825-44-4)

Guidance literature:

With polyphosphoric acid; at 85 ℃; for 2h;

DOI:10.3184/174751911X13057348859515

Reference yield: 75.0%

→ 3-Carboxy-5-methoxy-indanon (17825-44-4)

Guidance literature:

Reference yield:

3-methoxy-benzaldehyde (591-31-1) → 3-Carboxy-5-methoxy-indanon (17825-44-4)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine; acetic acid / toluene / Reflux

2: potassium cyanide / water; ethanol

3: polyphosphoric acid / 90 °C

With piperidine; potassium cyanide; acetic acid; In ethanol; water; toluene;

DOI:10.1039/c5ob00350d

upstream raw materials:

3-(3-Methoxyphenyl)succinic acid

3-methoxy-benzaldehyde

2-cyano-3-(3-methoxyphenyl)acrylic acid ethyl ester

Downstream raw materials:

6-methoxy-1-indane-carboxylic acid

Refernces

• 1、 Gan, Zongjie,Zhang, Di,Cao, Zhe,Xu, Yungen. "An improved synthesis of substituted indan-1-carboxylic acid". experimental part. p. 317 - 319. Retrieved 2011/10/04.
• 2、 -. "Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof". Page/Page column 8. . Retrieved 2009/12/02.