2(1H)-Quinolinone, 7-hydroxy-4-(methoxymethyl)-6-methyl- (9CI)

Base Information

• Chemical Name: 2(1H)-Quinolinone, 7-hydroxy-4-(methoxymethyl)-6-methyl- (9CI)
• CAS No.: 406169-90-2
• Molecular Formula: C12H13NO3
• Molecular Weight: 219.23700
• Mol file: 406169-90-2.mol

Synonyms:7-hydroxy-4-methoxymethyl-6-methylquinolin-2-one;2(1H)-Quinolinone, 7-hydroxy-4-(methoxymethyl)-6-methyl-;

Chemical Property of 2(1H)-Quinolinone, 7-hydroxy-4-(methoxymethyl)-6-methyl- (9CI)

Chemical Property:

• PSA: 62.32000
• LogP: 1.68850

Purity/Quality:

7-hydroxy-4-(methoxymethyl)-6-methylquinolin-2(1H)-one 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2(1H)-Quinolinone, 7-hydroxy-4-(methoxymethyl)-6-methyl- (9CI)

There total 3 articles about 2(1H)-Quinolinone, 7-hydroxy-4-(methoxymethyl)-6-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

7-amino-4-methoxymethyl-6-methylquinolin-2-one (406169-89-9) → 7-hydroxy-4-methoxymethyl-6-methylquinolin-2(1H)-one (406169-90-2)

Guidance literature:

7-amino-4-methoxymethyl-6-methylquinolin-2-one; With sulfuric acid; water; sodium nitrite; at 0 ℃;

With sulfuric acid; at 160 ℃; Further stages.;

DOI:10.1021/jm010993r

Reference yield:

ethyl 4-methoxy-3-oxobutanoate (66762-68-3) → 7-hydroxy-4-methoxymethyl-6-methylquinolin-2(1H)-one (406169-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 56 percent / 24 h / 150 °C

2.1: NaNO₂; conc. H₂SO₄; H₂O / 0 °C

2.2: 62 percent / aq. H₂SO₄ / 160 °C

With sulfuric acid; water; sodium nitrite;

DOI:10.1021/jm010993r

Reference yield:

4-methylbenzene-1,3-diamine (95-80-7,71111-07-4) → 7-hydroxy-4-methoxymethyl-6-methylquinolin-2(1H)-one (406169-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 56 percent / 24 h / 150 °C

2.1: NaNO₂; conc. H₂SO₄; H₂O / 0 °C

2.2: 62 percent / aq. H₂SO₄ / 160 °C

With sulfuric acid; water; sodium nitrite;

DOI:10.1021/jm010993r

upstream raw materials:

7-amino-4-methoxymethyl-6-methylquinolin-2-one

ethyl 4-methoxy-3-oxobutanoate

4-methylbenzene-1,3-diamine

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