66762-68-3

Basic information

• Product Name: ETHYL 4-METHOXY-3-OXO-BUTANOATE
• Synonyms: ETHYL 4-METHOXY-3-OXO-BUTANOATE;ETHYL 4-METHOXYACETOACETATE;4-methoxy-acetoacetic acid ethyl ester;Ethyl 4-methoxy-3-oxobutanoate, Ethyl 4-methoxy-3-oxobutryate;Butanoic acid, 4-methoxy-3-oxo-, ethyl ester;4-Methoxy-3-oxo-butanoic acid ethyl ester
• CAS NO: 66762-68-3
• Molecular Formula: C₇H₁₂O₄
• Molecular Weight: 160.17
• Mol File: 66762-68-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 68-71 °C(Press: 5 Torr)
• Appearance: /
• Density: 1.060±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.90±0.46(Predicted)
• CAS DataBase Reference: ETHYL 4-METHOXY-3-OXO-BUTANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-METHOXY-3-OXO-BUTANOATE(66762-68-3)
• EPA Substance Registry System: ETHYL 4-METHOXY-3-OXO-BUTANOATE(66762-68-3)

Safety Data

• Hazardous Substances Data: 66762-68-3(Hazardous Substances Data)

Usage

General Description

Ethyl 4-methoxy-3-oxo-butanoate, also known as ethyl 4-methoxy-3-oxobutyrate, is an organic compound used in the synthesis of pharmaceuticals, fragrances, and flavorings. It is an ester, characterized by its fruity, sweet aroma, and is commonly used as a flavoring agent in food and beverages. This chemical is also used in the production of perfumes and cosmetics for its pleasant scent. Additionally, it is utilized in the pharmaceutical industry as an intermediate in the synthesis of various drugs and medical compounds. Overall, ethyl 4-methoxy-3-oxo-butanoate has a wide range of applications in different industries due to its aromatic and chemical properties.

Upstream product

• 638-07-3 ethyl (2-chloroaceto)acetate 
• 2033-24-1 cycl-isopropylidene malonate 
• 625-45-6 2-methoxyacetic acid 
• 64-17-5 ethanol 
• 41051-15-4 4-methoxyacetoacetic acid methylester 
• 67-56-1 methanol 
• 105-36-2 ethyl bromoacetate 
• 38870-89-2 Methoxyacetyl chloride 
• 13176-46-0 4-bromoethyl acetoacetate 
• 124-41-4 sodium methylate 

Downstream Products

• 67230-31-3 C₁₇H₂₄N₂O₆ 
• 35339-97-0 Methyl-5-methyl-2-methoxy-methyl-3-furoat 
• 339278-89-6 6-methoxymethyl-2-phenylpyrimidin-4-ol 
• 325685-59-4 4-chloro-6-methoxymethyl-2-phenylpyrimidine 
• 1256447-57-0 C₁₅H₁₄N₄O₃ 
• 157101-77-4 7-hydroxy-4-(methoxymethyl)coumarin 
• 3122-78-9 4-methoxymethyl-6-hydroxypyrimidine 
• 140171-55-7 4-(2-Chloro-phenyl)-2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-6-methoxymethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 

Relevant articles and documents

5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS

The present invention discloses 5-[3-[piperazin-l-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives according to Formula (I), wherein R1, R2, R3a, R3b, R6a, R6b, the subscript n and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS 4 and 5 for the prophylaxis or treatment of inflammatory diseases or diseases involving degradation of cartilage or disruption of cartilage homeostasis, such as e.g. osteoarthritis.

Synthetic method of 4-methoxyethyl acetoacetate

The invention discloses a synthetic method of 4-methoxyethyl acetoacetate. The method concretely comprises the following steps: 1, adding tetrahydrofuran to a reaction kettle, introducing an inert gas, setting the internal temperature to be 15-25DEG C, adding sodium hydride, controlling the system temperature to be 20DEG C, adding a methanol and 4-chloroethyl acetoacetate mixed liquor in a dropwise manner, reacting for 4-6h, heating the obtained system to 20-25DEG C, continuously reacting for 3-5h, and carrying out TLC detection until the reaction is finished; 2, cooling the above reaction system to -7-0DEG C, adding a hydrochloric acid solution to adjust the pH value of the reaction system to 11-13, and carrying out pumping filtration on the above obtained reaction solution to obtain a white solid; and 3, adding the obtained white solid to ethyl acetate, adding the hydrochloric acid solution in a dropwise manner at 0DEG C to gradually dissolve the solid and adjust the pH value of the reaction system to 2-4, carrying out pumping filtration on the obtained reaction solution, separating out an organic layer from the obtained filtrate, decolorizing the organic phase through a decolorizing agent, and steaming out the above solvent to obtain pure 4-methoxyethyl acetoacetate. The method has the advantages of implementation of the reaction at room temperature, obtaining of the above product after steaming at a low temperature, direct and effective reduction of the danger in the production process, and reduction of the content of impurities in the product.

Discovery of novel dihydroimidazothiazole derivatives as p53-MDM2 protein-protein interaction inhibitors: Synthesis, biological evaluation and structure-activity relationships

Starting with Nutlins as an initial lead, we designed and generated bicyclic scaffolds aiming to place cis-bischlorophenyl moiety at the equivalent location where the hydrophobic interaction with MDM2 could be expected. As a result, we discovered novel MDM2 inhibitors possessing a dihydroimidazothiazole scaffold. Further exploration of the side chains on the dihydroimidazothiazole scaffold aided by molecular modeling resulted in compounds exhibiting almost comparable in vitro potency to Nutlin-3a.