DEHYDROACETIC ACID

Base Information

• Chemical Name: DEHYDROACETIC ACID
• CAS No.: 16807-48-0
• Molecular Formula: C8H8 O4
• Molecular Weight: 168.149
• Mol file: 16807-48-0.mol

Synonyms:DHAA;Dehydracetic acid; Dehydroacetic acid

Chemical Property of DEHYDROACETIC ACID

Chemical Property:

• Vapor Pressure: 0.000144mmHg at 25°C
• Melting Point: 109-112℃
• Boiling Point: 332.6°C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 150.5°C
• PSA: 60.44000
• Density: 1.264g/cm³
• LogP: 0.22130

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): R22:
• Hazard Codes: Xn:Harmful
• Statements: R22:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of DEHYDROACETIC ACID

There total 1 articles about DEHYDROACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

ethyl acetoacetate (141-97-9) → 3‐acetyl‐2‐hydroxy‐6‐methyl‐4H‐pyran‐4‐one (16807-48-0) + 2,7-dimethyl-4H-pyrano<3,2-c>-2H-pyran-4,5-dione (33176-11-3)

Guidance literature:

With sodium hydrogencarbonate; at 180 ℃; for 8h; Mechanism;

Reference yield: 94.0%

3‐acetyl‐2‐hydroxy‐6‐methyl‐4H‐pyran‐4‐one (16807-48-0) + N-amino-(4-nitrophenyl)carboxamide (636-97-5) → (E)-N'-[1-(2-hydroxy-6-methyl-4-oxo-4H-pyran-3-yl)ethylidene]-4-nitrobenzohydrazide

Guidance literature:

With acetic acid; In ethanol; for 4h; Reflux;

DOI:10.1134/S1070363219010250

Reference yield: 85.0%

3‐acetyl‐2‐hydroxy‐6‐methyl‐4H‐pyran‐4‐one (16807-48-0) + N?(2?aminophenyl)?2?(5?methyl?1H?pyrazol?3?yl)acetamide (111736-10-8) → (E)?N?(2?(1?(2?hydroxy?6?methyl?4?oxo?4H?pyran?3?yl)ethylideneamino)phenyl)?2?(5?methyl?1H?pyrazol?3?yl)acetamide

Guidance literature:

In ethanol; at 20 ℃; for 24h;

DOI:10.1016/j.jinorgbio.2018.11.006

upstream raw materials:

ethyl acetoacetate

Downstream raw materials:

2,7-dimethyl-4H-pyrano<3,2-c>-2H-pyran-4,5-dione

2-Methyl-1H-benzimidazole

1,3-dihydro-2H-benzimidazol-2-one

4-(2-oxopropylidene)-1,2,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

Refernces