5-Chloro-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Base Information

• Chemical Name: 5-Chloro-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
• CAS No.: 40852-06-0
• Molecular Formula: C₇H₆ClN₃O
• Molecular Weight: 183.597
• Hs Code.: 2933399990
• European Community (EC) Number: 878-706-0
• Mol file: 40852-06-0.mol

Synonyms:40852-06-0;5-Chloro-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one;5-chloro-1-methyl-3H-imidazo[4,5-b]pyridin-2-one;2H-Imidazo[4,5-b]pyridin-2-one, 5-chloro-1,3-dihydro-1-methyl-;MFCD24563468;1-methyl-5-chloro-1,3-dihydro-imidazo-(4,5-b)-pyridin-2-one;SCHEMBL3667046;SCHEMBL11435434;CRMDODRROWFDQK-UHFFFAOYSA-N;AC2058;AKOS027256948;CS-12065;SY036666;DB-216172;CS-0452252;A914352;5-chloro-1-methyl-1h-imidazo[4,5-b]pyridin-2-ol

Chemical Property of 5-Chloro-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 183.0199395
• Heavy Atom Count: 12
• Complexity: 211

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1C2=C(NC1=O)N=C(C=C2)Cl

Technology Process of 5-Chloro-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

There total 6 articles about 5-Chloro-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl N-(2-amino-6-chloro-3-pyridyl)-N-methylcarbamate (89660-18-4) → 1-methyl-5-chloroimidazo<4,5-b>pyridin-2-one (40852-06-0)

Guidance literature:

With sodium ethanolate; for 6h; Heating;

Reference yield:

6-Chloro-pyridin-3-ylamine (5350-93-6) → 1-methyl-5-chloroimidazo<4,5-b>pyridin-2-one (40852-06-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 79.5 percent / CHCl₃ / 8 h / Heating

2: 62 percent / conc. H₂SO₄, 100percent HNO₃ / 0.33 h / 90 - 95 °C

3: K₂CO₃ / acetone / 6 h / Heating

4: 70 percent / 37percent HCl, granulated tin / 0.25 h / Heating

5: 95 percent / EtONa / 6 h / Heating

With hydrogenchloride; tin; sulfuric acid; nitric acid; sodium ethanolate; potassium carbonate; In chloroform; acetone;

Reference yield:

ethyl (2-chloro-5-pyridyl)carbamate (89660-15-1) → 1-methyl-5-chloroimidazo<4,5-b>pyridin-2-one (40852-06-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 62 percent / conc. H₂SO₄, 100percent HNO₃ / 0.33 h / 90 - 95 °C

2: K₂CO₃ / acetone / 6 h / Heating

3: 70 percent / 37percent HCl, granulated tin / 0.25 h / Heating

4: 95 percent / EtONa / 6 h / Heating

With hydrogenchloride; tin; sulfuric acid; nitric acid; sodium ethanolate; potassium carbonate; In acetone;

upstream raw materials:

ethyl N-(2-amino-6-chloro-3-pyridyl)-N-methylcarbamate

6-Chloro-pyridin-3-ylamine

ethyl (2-chloro-5-pyridyl)carbamate

ethyl (6-chloro-2-nitro-3-pyridyl)carbamate

Downstream raw materials:

1-methyl-3-phenyl-5-chloroimidazo<4,5-b>pyridin-2-one

1-methyl-3-phenyl-5-chloroimidazo<4,5-b>pyridin-2-thione

1-methyl-3-(2-pyridyl)-5-chloroimidazo<4,5-b>pyridin-2-one

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