2-Propenoic acid, 3-(2-iodophenyl)-, methyl ester, (E)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-(2-iodophenyl)-, methyl ester, (E)-
• CAS No.: 40888-21-9
• Molecular Formula: C10H9IO2
• Molecular Weight: 288.085
• Mol file: 40888-21-9.mol

Synonyms:

Chemical Property of 2-Propenoic acid, 3-(2-iodophenyl)-, methyl ester, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenoic acid, 3-(2-iodophenyl)-, methyl ester, (E)-

There total 5 articles about 2-Propenoic acid, 3-(2-iodophenyl)-, methyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

trimethyl phosphonoacetate (5927-18-4) + 2-iodobenzaldehyde (26260-02-6) → methyl (E)-3-(2′-iodophenyl)acrylate (40888-21-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; 1.) r.t., 30 min, 2.) r.t., 19 h;

Reference yield: 68.0%

Malonic acid monomethyl ester (16695-14-0) + 2-iodobenzaldehyde (26260-02-6) → methyl (E)-3-(2′-iodophenyl)acrylate (40888-21-9)

Guidance literature:

With piperidine; pyridine; Reflux;

DOI:10.1002/adsc.202000751

Reference yield: 66.0%

2-iodophenylamine (615-43-0) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl (E)-3-(2′-iodophenyl)acrylate (40888-21-9)

Guidance literature:

2-iodophenylamine; With tert.-butylnitrite; boron trifluoride diethyl etherate; at -15 - 5 ℃; for 0.583333h;

acrylic acid methyl ester; With (R,R)-N,N'-(2-MeC₆H₄)2-N,N'-(cyclohexane-1,2-diyl)thiourea; palladium diacetate; In methanol; at 20 ℃; for 4h;

DOI:10.1021/ol036182u

upstream raw materials:

2-iodobenzaldehyde

methyl (triphenylphosphoranylidene)acetate

trimethyl phosphonoacetate

2-iodophenylamine

Downstream raw materials:

2-{tert-Butoxycarbonyl-[3-(2-iodo-phenyl)-propyl]-amino}-acrylic acid methyl ester

Refernces

• 1、 Karuppasamy, Muthu,Vachan,Jandial, Tanvi,Babiola Annes, Sesuraj,Bhuvanesh, Nattamai,Uma Maheswari,Sridharan, Vellaisamy. "Palladium(II)-Catalyzed Direct Access to Indeno[1,2-c]isochromen-5(11H)-Ones via Intramolecular Oxypalladation-Initiated Cascade Process". supporting information. p. 2716 - 2724. Retrieved 2020/06/01.
• 2、 Grigg, Ronald,Inman, Martyn,Kilner, Colin,K?ppen, Ines,Marchbank, John,Selby, Peter,Sridharan, Visuvanathar. "Synthesis of carbo- and heterocycles via palladium catalysed cascade allene insertion-nucleophile incorporation-Michael addition processes". . p. 6152 - 6169. Retrieved 2008/02/04.