3-[(Phenylsulfonyl)amino]thiophene-2-carboxylic acid

Base Information

Chemical Name:3-[(Phenylsulfonyl)amino]thiophene-2-carboxylic acid
CAS No.:409364-78-9
Molecular Formula:C11H9NO4S2
Molecular Weight:283.329
Hs Code.:
DSSTox Substance ID:DTXSID501216566
Mol file:409364-78-9.mol

Synonyms:3-[(phenylsulfonyl)amino]thiophene-2-carboxylic acid;409364-78-9;3-(benzenesulfonamido)thiophene-2-carboxylic acid;3-[(Phenylsulfonyl)amino]-2-thiophenecarboxylic acid;SCHEMBL532975;BFPYDKRUFUMDTD-UHFFFAOYSA-N;DTXSID501216566;STL112333;AKOS002435454;BS-9916;MCULE-1478674170;DB-151297;3-(Phenylsulfonamido)thiophene-2-carboxylic acid;3-benzenesulfonylaminothiophene-2-carboxylic acid;3-BENZENESULFONAMIDOTHIOPHENE-2-CARBOXYLIC ACID

Suppliers and Price of 3-[(Phenylsulfonyl)amino]thiophene-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[(Phenylsulfonyl)amino]thiophene-2-carboxylic acid

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:282.99730012
Heavy Atom Count:18
Complexity:398

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)S(=O)(=O)NC2=C(SC=C2)C(=O)O

Technology Process of 3-[(Phenylsulfonyl)amino]thiophene-2-carboxylic acid

There total 3 articles about 3-[(Phenylsulfonyl)amino]thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 409364-77-8
methyl 3-(phenylsulfonamido)thiophene-2-carboxylate

: 409364-78-9
3-benzenesulfonylaminothiophene-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In acetonitrile;

Reference yield:

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 409364-78-9
3-benzenesulfonylaminothiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 0.5 h / 0 °C

1.2: 16 h / 20 °C

2.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 20 °C

With pyridine; lithium hydroxide monohydrate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bioorg.2020.103754

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 409364-78-9
3-benzenesulfonylaminothiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 0.5 h / 0 °C

1.2: 16 h / 20 °C

2.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 20 °C

With pyridine; lithium hydroxide monohydrate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bioorg.2020.103754