1-Methoxy-5-methylnaphthalene

Base Information

• Chemical Name: 1-Methoxy-5-methylnaphthalene
• CAS No.: 41037-15-4
• Molecular Formula: C12H12O
• Molecular Weight: 172.22300
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID00450389
• Nikkaji Number: J2.218.493H
• Wikidata: Q82270083
• Mol file: 41037-15-4.mol

Synonyms:1-Methoxy-5-methylnaphthalene;41037-15-4;1-Methyl-5-methoxynaphthalene;5-Methoxy-1-methylnaphthalene;SCHEMBL9005269;1-Methoxy-5-methyl naphthalene;DTXSID00450389;IJMNLZFOUKUMTJ-UHFFFAOYSA-N;FT-0728713

Chemical Property of 1-Methoxy-5-methylnaphthalene

Chemical Property:

• PSA: 9.23000
• LogP: 3.15680
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 172.088815002
• Heavy Atom Count: 13
• Complexity: 167

Purity/Quality:

97% ^*data from raw suppliers

5-Methoxy-1-methylnaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C=CC=C(C2=CC=C1)OC

Technology Process of 1-Methoxy-5-methylnaphthalene

There total 5 articles about 1-Methoxy-5-methylnaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-dihydro-4-methyl-8-methoxynaphthalene (90295-47-9) → 1-Methoxy-5-methyl-naphthalin (41037-15-4)

Guidance literature:

palladium on activated charcoal; In Triethylene glycol dimethyl ether; for 72h; Heating;

DOI:10.1021/jm040112r

Reference yield:

5-Methoxy-1-methyl-1,2,3,4-tetrahydro-naphthalen-1-ol (865070-96-8) → 1-Methoxy-5-methyl-naphthalin (41037-15-4)

Guidance literature:

5-Methoxy-1-methyl-1,2,3,4-tetrahydro-naphthalen-1-ol; With toluene-4-sulfonic acid; In toluene; for 4h; Heating;

With sulfur; at 210 ℃; for 3h;

DOI:10.1023/B:RUGC.0000018662.02489.8d

Reference yield:

5-Methoxy-1-tetralone (33892-75-0) → 1-Methoxy-5-methyl-naphthalin (41037-15-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diethyl ether / 3 h / Heating

2.1: p-toluenesulfonic acid / toluene / 4 h / Heating

2.2: 459 mg / S / 3 h / 210 °C

With toluene-4-sulfonic acid; In diethyl ether; toluene;

DOI:10.1023/B:RUGC.0000018662.02489.8d

upstream raw materials:

5-Methoxy-1-methyl-1,2,3,4-tetrahydro-naphthalen-1-ol

1,2-dihydro-4-methyl-8-methoxynaphthalene

5-Methoxy-1-tetralone

Downstream raw materials:

1-(2-bromo-5-methyl-naphthalen-1-yloxy)-propan-2-one

4-hydroxy-7-methyl-benzo[h]chromen-2-one