5-Methoxy-1-tetralone

Base Information

• Chemical Name: 5-Methoxy-1-tetralone
• CAS No.: 33892-75-0
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Hs Code.: 2914509090
• European Community (EC) Number: 251-723-5
• NSC Number: 310000
• UNII: 75E8EE6Y3X
• DSSTox Substance ID: DTXSID70187514
• Nikkaji Number: J42.442K
• Wikidata: Q72486157
• Mol file: 33892-75-0.mol

Synonyms:5-Methoxy-1-tetralone;33892-75-0;5-methoxy-3,4-dihydronaphthalenone;5-methoxy-3,4-dihydronaphthalen-1(2H)-one;5-methoxy-3,4-dihydro-2H-naphthalen-1-one;1(2H)-NAPHTHALENONE, 3,4-DIHYDRO-5-METHOXY-;5-methoxytetralone;5-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one;alpha-Tetralone, 5-methoxy-;MFCD00001692;5-methoxytetralin-1-one;EINECS 251-723-5;NSC 310000;BRN 2047383;75E8EE6Y3X;3,4-Dihydro-5-methoxy-1(2H)-naphthalenone;NSC-310000;4-08-00-00903 (Beilstein Handbook Reference);NSC310000;UNII-75E8EE6Y3X;SCHEMBL264705;5-Methoxy-1-tetralone, 97%;.alpha.-Tetralone, 5-methoxy-;DTXSID70187514;AM918;BBL027353;STK802188;AKOS005206962;CS-W007742;FS-2832;MB00106;LS-95064;SY030944;1(2H)-Naphthalenone,4-dihydro-5-methoxy-;5-Methoxy-3,4-dihydro-1(2H)-naphthalenone;FT-0602405;M2297;5-methoxy-3,4-dihydronaphthalen-1 (2H)-one;EN300-91809;5-Methoxy-3,4-dihydro-1(2H)-naphthalenone #;O11465;3, 4-dihydro-5-methoxy-[2H)-napthalen-1-one;5-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene;A821985;J-019361;J-517689;5-METHOXY-1,2,3,4-TETRAHYDRO-1-OXONAPHTHALENE

Chemical Property of 5-Methoxy-1-tetralone

Chemical Property:

• Vapor Pressure: 0.287mmHg at 25°C
• Melting Point: 87-91 °C(lit.)
• Refractive Index: 1.565
• Boiling Point: 313 °C at 760 mmHg
• Flash Point: 153.1 °C
• PSA: 26.30000
• Density: 1.124 g/cm³
• LogP: 2.21420
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 176.083729621
• Heavy Atom Count: 13
• Complexity: 200

Purity/Quality:

97% ^*data from raw suppliers

5-Methoxy-1-tetralone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-24/25-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1CCCC2=O
• Uses: 5-Methoxy-1-tetralone is used in the preparation of hydroxy ketone.

Technology Process of 5-Methoxy-1-tetralone

There total 27 articles about 5-Methoxy-1-tetralone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-Hydroxy-1-tetralone (28315-93-7) + methyl iodide (74-88-4) → 5-Methoxy-1-tetralone (33892-75-0)

Guidance literature:

5-Hydroxy-1-tetralone; With potassium carbonate; for 0.5h;

methyl iodide; for 12h;

DOI:10.1002/anie.201711221

Reference yield: 86.0%

5-methoxy-1-tetralone oxime (30069-58-0) → 5-Methoxy-1-tetralone (33892-75-0)

Guidance literature:

clay supported NH₄NO₃; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1080/00397919808004828

Reference yield: 76.0%

5-methoxy-3,4-dihydro-2H-naphthalen-1-one oxime (30069-58-0) → 5-Methoxy-1-tetralone (33892-75-0)

Guidance literature:

With clay supported NH₄NO₃; for 0.0305556h; Irradiation; microwave irradiation;

DOI:10.1080/00397919808004475

upstream raw materials:

8-chloro-5-methoxy-3,4-dihydronaphthalen-1(2H)-one

1,5-dihydroxynaphthalene

4-(2-Methoxyphenyl)-butanoic acid

ethoxydimethylvinylsilane

Downstream raw materials:

methyl-(5-phenyl-7,8-dihydro-[1]naphthyl)-ether

1-(4-Methoxyphenyl)-5-methoxy-3,4-dihydronaphthalin

5-Methoxy-2-(phenethylamino-methyl)-3,4-dihydro-2H-naphthalen-1-one

1-Methylamino-5-methoxy-1,2,3,4-tetrahydronaphthalin