3-(1-Naphthalenyloxy)propiophenone

Base Information

• Chemical Name: 3-(1-Naphthalenyloxy)propiophenone
• CAS No.: 41198-42-9
• Molecular Formula: C19H16O2
• Molecular Weight: 276.335
• Mol file: 41198-42-9.mol

Synonyms:3-naphthalen-1-yloxy-1-phenylpropan-1-one;

Chemical Property of 3-(1-Naphthalenyloxy)propiophenone

Chemical Property:

• Melting Point: 90-92°C
• PSA: 26.30000
• LogP: 4.49160
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Very Slightly, Heated)

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-(1-Naphthalenyloxy)propiophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An impurity of Dapoxetine (D185700). 3-(1-Naphthalenyloxy)propiophenone is an impurity of Dapoxetine (D185700).

Technology Process of 3-(1-Naphthalenyloxy)propiophenone

There total 4 articles about 3-(1-Naphthalenyloxy)propiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

α-naphthol (90-15-3) + 3-chloropropiophenone (936-59-4) → 3-(naphthalen-1-yloxy)-1-phenylpropan-1-one (41198-42-9)

Guidance literature:

With tetrabutylammomium bromide; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; water; at 20 ℃; for 42h; Temperature; Solvent; Large scale;

Reference yield: 92.7%

2-[2-(1-naphthyloxy)ethyl]-2-phenyl-1,3-dioxolane → 3-(naphthalen-1-yloxy)-1-phenylpropan-1-one (41198-42-9)

Guidance literature:

With toluene-4-sulfonic acid; In acetone; at 78 ℃; for 2h;

Reference yield: 75.0%

3-(naphthalen-1-yloxy)-1-phenyl-propan-1-ol (908291-72-5) → 3-(naphthalen-1-yloxy)-1-phenylpropan-1-one (41198-42-9)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 25 - 30 ℃; for 12h;

DOI:10.1021/op300034u

upstream raw materials:

3-(naphthalen-1-yloxy)-1-phenyl-propan-1-ol

3-chloropropiophenone

α-naphthol

Downstream raw materials:

Dapoxetine hydrochloride

(R)-(-)-3-(1-naphthalenyloxy)-1-phenyl-1-propanol

Didesmethyldapoxetine

1-phenyl-3-(naphthyl-1-oxy)propylamine