10.1016/S1872-2067(12)60693-7
The study focuses on the synthesis of 4H-pyran derivatives using a silica-bonded N-propylpiperazine sodium n-propionate (SBPPSP) as a recyclable catalyst. The catalyst was prepared from commercially available and inexpensive starting materials and was used to catalyze the synthesis of various 4H-pyran derivatives, including 3,4-dihydropyrano[c]chromenes, 2-amino-4H-pyrans, 1,4-dihydropyrano[2,3-c]pyrazoles, and 2-amino-4H-benzo[e]chromenes. The chemicals used in the study included aromatic aldehydes, malononitrile, dimedone, ethyl acetoacetate, 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one, and α-naphthol, which served as reactants in the multi-component reactions to form the desired 4H-pyran derivatives. The purpose of these chemicals was to participate in condensation reactions under refluxing aqueous ethanol conditions, with SBPPSP facilitating the process and being easily recoverable and reusable, highlighting the environmental and economic benefits of the method.
10.1021/jm00163a058
The research focused on the synthesis, biological evaluation, and structure-activity relationships of a series of 2-substituted-1-naphthols, which are potent inhibitors of 5-lipoxygenase (5-LO) and cyclooxygenase (CO) enzymes. These compounds were investigated for their potential as topical anti-inflammatory agents, particularly for treating inflammatory skin diseases like psoriasis and contact dermatitis. The study concluded that 2-substituted-1-naphthols, especially 2-(arylmethyl)-1-naphthols, showed significant anti-inflammatory potency in a mouse model, with DuP 654 (2-benzyl-1-naphthol) demonstrating an attractive profile for topical anti-inflammatory activity and being considered for clinical trials as a topically applied antipsoriatic agent. The research involved a variety of chemicals, including 1-naphthols, arylmethyl derivatives, and several synthetic peptides, which were tested for their inhibitory effects on 5-LO and CO, as well as their ability to reduce ear edema in mice induced by arachidonic acid. The study provided insights into the structure-activity relationships of these compounds, highlighting the importance of specific substituents on the naphthalene ring for enzyme inhibition and anti-inflammatory activity.
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