2-Piperidinone, 5-(4-chlorophenyl)-

Base Information

Chemical Name:2-Piperidinone, 5-(4-chlorophenyl)-
CAS No.:41216-03-9
Molecular Formula:C11H12ClNO
Molecular Weight:209.67200
Hs Code.:
Mol file:41216-03-9.mol

Synonyms:5-(4-chlorophenyl)piperidin-2-one;5-(4-Chloro-phenyl)-piperidin-2-one;5-(p-Chlorphenyl)-2-piperidon;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Piperidinone, 5-(4-chlorophenyl)-

Chemical Property:

PSA：29.10000
LogP:2.66240

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 2-Piperidinone, 5-(4-chlorophenyl)-

There total 11 articles about 2-Piperidinone, 5-(4-chlorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 537048-31-0
1-benzyl-5-(4-chloro-phenyl)-3,4-dihydro-1H-pyridin-2-one

: 41216-03-9
(RS)-5-(4-chlorophenyl)-2-piperidone

: N-benzyl-5-(4-chlorophenyl)piperidin-2-one

Guidance literature:: With hydrogen; palladium dihydroxide; In acetic acid; at 20 ℃; for 18h;
DOI:10.3987/com-02-9626

Reference yield:

: 537048-29-6
N-benzyl-3-[(4-methylphenyl)sulfonyl]-5-(4-chlorophenyl)-3,4-dihydro-2(1H)-pyridinone

: 41216-03-9
(RS)-5-(4-chlorophenyl)-2-piperidone

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / sodium phosphate; Na(Hg) / methanol / 2 h / 20 °C

2: 80 percent / H₂ / Pd(OH)2 / acetic acid / 18 h / 20 °C

With sodium amalgam; hydrogen; sodium phosphate; palladium dihydroxide; In methanol; acetic acid;
DOI:10.3987/com-02-9626

Reference yield:

: 537048-28-5
N-benzyl-3-(4-chlorophenyl)-5-(4-methylphenylsulfonyl)piperidine-2,6-dione

: 41216-03-9
(RS)-5-(4-chlorophenyl)-2-piperidone

Guidance literature:: Multi-step reaction with 4 steps

1: NaH; LAH / tetrahydrofuran / 1.08 h / 20 °C

2: BF₃*OEt₂ / CH₂Cl₂ / 10 h

3: 88 percent / sodium phosphate; Na(Hg) / methanol / 2 h / 20 °C

4: 80 percent / H₂ / Pd(OH)2 / acetic acid / 18 h / 20 °C

With lithium aluminium tetrahydride; sodium amalgam; boron trifluoride diethyl etherate; hydrogen; sodium hydride; sodium phosphate; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; acetic acid;
DOI:10.3987/com-02-9626