8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride

Base Information

• Chemical Name: 8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride
• CAS No.: 41266-63-1
• Molecular Formula: C11H11FN2.ClH
• Molecular Weight: 226.681
• European Community (EC) Number: 824-145-1
• Mol file: 41266-63-1.mol

Synonyms:41266-63-1;8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride;8-fluoro-1H,2H,3H,4H,5H-pyrido[4,3-b]indole hydrochloride;8-Fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole;hydrochloride;SCHEMBL21630948;EN300-175956;F80747;A857092;8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indolehydrochloride

Chemical Property of 8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride

Chemical Property:

• Melting Point: 259 - 261 °C
• PSA: 27.82000
• LogP: 3.08350
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 226.0673042
• Heavy Atom Count: 15
• Complexity: 221

Purity/Quality:

97% ^*data from raw suppliers

8-Fluoro-1H,2H,3H,4H,5H-pyrido[4,3-b]indoleHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CNCC2=C1NC3=C2C=C(C=C3)F.Cl

Technology Process of 8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride

There total 2 articles about 8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

piperidin-4-one (41661-47-6) + 4-fluorophenyhydrazine hydrochloride (823-85-8) → 8-fluoro-2,3,4,5-tetrahydro-1H-pyrido<4,3-b>indole hydrochloride (41266-63-1)

Guidance literature:

In ethanol; for 2h; Heating;

DOI:10.1002/jhet.5570430308

Reference yield: 44.2%

4-piperidone hydrochloride (41979-39-9) + 4-fluorophenyhydrazine hydrochloride (823-85-8) → 8-fluoro-2,3,4,5-tetrahydro-1H-pyrido<4,3-b>indole hydrochloride (41266-63-1)

Guidance literature:

In ethanol; for 2h; Reflux;

Reference yield: 67.8%

2-(methoxyphenoxy)ethylbromide (4463-59-6) + 8-fluoro-2,3,4,5-tetrahydro-1H-pyrido<4,3-b>indole hydrochloride (41266-63-1) → C20H21FN2O2

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 24h;

upstream raw materials:

piperidin-4-one

4-fluorophenyhydrazine hydrochloride

4-piperidone hydrochloride

Refernces

• 1、 Bridoux, Alexandre,Goossens, Laurence,Houssin, Raymond,Henichart, Jean-Pierre. "Synthesis of 8-substituted tetrahydro-γ-carbolines". . p. 571 - 578. Retrieved 2007/10/03.