3-Hydroxy-5-phenylpyrazine-2-carboxylic acid

Base Information

Chemical Name:3-Hydroxy-5-phenylpyrazine-2-carboxylic acid
CAS No.:41270-60-4
Molecular Formula:C11H8N2O3
Molecular Weight:216.196
Hs Code.:
DSSTox Substance ID:DTXSID501219215
Mol file:41270-60-4.mol

Synonyms:41270-60-4;3-hydroxy-5-phenylpyrazine-2-carboxylic acid;2-oxo-6-phenyl-1H-pyrazine-3-carboxylic acid;SCHEMBL6987949;DTXSID501219215;3-hydroxy-5-phenylpyrazine-2-carboxylicacid;FT-0767783;EN300-304355;3,4-Dihydro-3-oxo-5-phenyl-2-pyrazinecarboxylic acid

Suppliers and Price of 3-Hydroxy-5-phenylpyrazine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 3-Hydroxy-5-phenylpyrazine-2-carboxylic acid

Chemical Property:

XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:216.05349212
Heavy Atom Count:16
Complexity:379

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CN=C(C(=O)N2)C(=O)O

Technology Process of 3-Hydroxy-5-phenylpyrazine-2-carboxylic acid

There total 8 articles about 3-Hydroxy-5-phenylpyrazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1503-43-1
amino-3-phenyl-5-pyrazinecarboxylate-2 de methyle

: 41270-60-4
3-oxo-5-phenyl-3,4-dihydro-pyrazine-2-carboxylic acid

Guidance literature:: amino-3-phenyl-5-pyrazinecarboxylate-2 de methyle; With tert.-butylnitrite; sulfuric acid; In tetrahydrofuran; acetonitrile; at 0 - 20 ℃; for 2h;

With sodium hydroxide; In tetrahydrofuran; acetonitrile;

Reference yield:

: 98-80-6
phenylboronic acid

: 41270-60-4
3-oxo-5-phenyl-3,4-dihydro-pyrazine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; methanol / 4 h / 85 °C / Inert atmosphere

2: tert.-butylnitrite; sulfuric acid / acetonitrile; tetrahydrofuran / 2 h / 0 - 20 °C

With tert.-butylnitrite; sulfuric acid; water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; toluene; acetonitrile;

Reference yield:

: 28643-16-5
3-amino-5-chloro-pyrazine-2-carboxylic acid methyl ester

: 41270-60-4
3-oxo-5-phenyl-3,4-dihydro-pyrazine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; methanol / 4 h / 85 °C / Inert atmosphere

2: tert.-butylnitrite; sulfuric acid / acetonitrile; tetrahydrofuran / 2 h / 0 - 20 °C

With tert.-butylnitrite; sulfuric acid; water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; toluene; acetonitrile;