(1R,2R)-2-(4-chlorophenyl)cyclopropanecarboxylic acid

Base Information

Chemical Name:(1R,2R)-2-(4-chlorophenyl)cyclopropanecarboxylic acid
CAS No.:4157-47-5
Molecular Formula:C₁₀H₉ClO₂
Molecular Weight:196.633
Hs Code.:
European Community (EC) Number:847-040-2
DSSTox Substance ID:DTXSID60426368
Nikkaji Number:J3.631.444C
Wikidata:Q82239294

Synonyms:(1R,2R)-2-(4-chlorophenyl)cyclopropanecarboxylic acid;31501-86-7;4157-47-5;(1R,2R)-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid;rac-(1r,2r)-2-(4-Chlorophenyl)cyclopropane-1-carboxylic acid;trans-2-(4-chlorophenyl)cyclopropanecarboxylic acid;rel-(1R,2R)-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid;starbld0021730;SCHEMBL4210867;DTXSID60426368;JZYXJKBNUJJIKU-DTWKUNHWSA-N;AC8131;AC9688;AKOS030592683;BS-51680;CS-0197142;J3.631.444C;EN300-207257;EN300-255239;Trans 2-(4-chlorophenyl)cyclopropanecarboxylic Acid;trans-2-(4-chloro-phenyl)cyclopropanecarboxylic acid;Z2306910175;(+/-)-trans-2-(4-chlorophenyl)cyclopropanecarboxylic acid;(1R,2R)-2-(4-Chloro-phenyl)-cyclopropanecarboxylic acid;(1R,2R)-2alpha-(4-Chlorophenyl)cyclopropane-1beta-carboxylic acid

Suppliers and Price of (1R,2R)-2-(4-chlorophenyl)cyclopropanecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of (1R,2R)-2-(4-chlorophenyl)cyclopropanecarboxylic acid

Chemical Property:

PSA：37.30000
LogP:2.52810
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:196.0291072
Heavy Atom Count:13
Complexity:209

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C1C(=O)O)C2=CC=C(C=C2)Cl
Isomeric SMILES:C1[C@H]([C@@H]1C(=O)O)C2=CC=C(C=C2)Cl

Technology Process of (1R,2R)-2-(4-chlorophenyl)cyclopropanecarboxylic acid

There total 17 articles about (1R,2R)-2-(4-chlorophenyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 75-47-8
iodoform

: 1615-02-7,940-62-5
3-(4-chlorophenyl)prop-2-enoic acid

: 4157-47-5,31501-86-7,90940-40-2,142758-86-9,142758-87-0,142793-24-6,142796-15-4
(±)-trans-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid

Guidance literature:: With samarium; In tetrahydrofuran; for 1h; sonication;
DOI:10.1021/ol0709174

Reference yield: 75.0%

: 4103-56-4,4103-57-5,91393-54-3
ethyl trans-2-(4-chlorophenyl)cyclopropane-1-carboxylate

: 4157-47-5,31501-86-7,90940-40-2,142758-86-9,142758-87-0,142793-24-6,142796-15-4
(±)-trans-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; at 20 ℃; for 5h;
DOI:10.1007/s00706-017-2026-5

Reference yield:

: 623-73-4
diazoacetic acid ethyl ester

: 1073-67-2,24991-47-7
4-vinylbenzyl chloride

: 4157-47-5,31501-86-7,90940-40-2,142758-86-9,142758-87-0,142793-24-6,142796-15-4
(±)-trans-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid

Guidance literature:: diazoacetic acid ethyl ester; 4-vinylbenzyl chloride; dirhodium tetraacetate; In toluene; at 80 - 85 ℃; for 1.5h;

With sodium methylate; In ethanol; for 18h; Heating;

With lithium hydroxide; In methanol; water; at 70 ℃;
DOI:10.1016/j.bmc.2006.10.002