2-Bromoethyl Dichlorophosphate

Base Information

• Chemical Name: 2-Bromoethyl Dichlorophosphate
• CAS No.: 4167-02-6
• Molecular Formula: C2H4BrCl2O2P
• Molecular Weight: 241.836
• Hs Code.: 2931900090
• European Community (EC) Number: 695-191-6
• DSSTox Substance ID: DTXSID80405539
• Nikkaji Number: J834.683F
• Wikidata: Q82210138
• Mol file: 4167-02-6.mol

Synonyms:4167-02-6;2-Bromoethyl Dichlorophosphate;2-Bromoethyl Phosphorodichloridate;1-bromo-2-dichlorophosphoryloxyethane;beta-bromoethylphosphoryl dichloride;(2-BROMOETHYL)-PHOSPHORYLCHLORIDE;SCHEMBL93503;bromoethyl phosphorodichloridate;b-Bromoethylphosphoryl Dichloride;?-Bromoethylphosphoryl Dichloride;DTXSID80405539;NYKRTKYIPKOPLK-UHFFFAOYSA-N;OLEICACIDMONOISOPROPANOLAMIDE;(2-bromoethoxy)phosphonoyl dichloride;beta -Bromoethylphosphoryl Dichloride;MFCD04116122;AKOS032455663;2-BROMOETHYL DICHLORIDOPHOSPHATE;SY299057;FT-0663732

Chemical Property of 2-Bromoethyl Dichlorophosphate

Chemical Property:

• Vapor Pressure: 0.0345mmHg at 25°C
• Boiling Point: 250.3oC at 760 mmHg
• Flash Point: 105.2oC
• PSA: 36.11000
• Density: 1.889g/cm3
• LogP: 2.98360
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 239.85093
• Heavy Atom Count: 8
• Complexity: 102

Purity/Quality:

98%Min ^*data from raw suppliers

β-BromoethylphosphorylDichloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CBr)OP(=O)(Cl)Cl
• Uses: A phosphorylating agent.

Technology Process of 2-Bromoethyl Dichlorophosphate

There total 3 articles about 2-Bromoethyl Dichlorophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-bromoethanol (540-51-2) → 2-bromoethylphosphoric acid dichloride (4167-02-6)

Guidance literature:

With trichlorophosphate; In dichloromethane; for 6h; Reflux;

Reference yield:

3-hexadecylthiocyclohexanol + 3-hexadecylthiocyclohexanone + 2-bromoethanol (540-51-2) → 2-bromoethylphosphoric acid dichloride (4167-02-6)

Guidance literature:

With sodium borohydrid; trichlorophosphate; In methanol; Trichloroethylene;

Reference yield:

→ 2-bromoethylphosphoric acid dichloride (4167-02-6)

Guidance literature:

DOI:10.1016/0009-3084(78)90002-6 DOI:10.1016/0009-3084(79)90075-6

upstream raw materials:

2-bromoethanol

Downstream raw materials:

Phosphoric acid 2-benzyloxy-docosyl ester 2-bromo-ethyl ester

Phosphoric acid 1-benzyloxymethyl-henicosyl ester 2-bromo-ethyl ester

1-O-hexadecyl-2-O-methyl-sn-glycero(3)phosphocholine

3-O-hexadecyl-2-O-benzyl-sn-glycero-1-phosphocholine

Refernces

• 1、 Jangir, Santosh,Bala, Veenu,Lal, Nand,Kumar, Lalit,Sarswat, Amit,Kumar, Amit,Hamidullah,Saini, Karan S.,Sharma, Vikas,Verma, Vikas,Maikhuri, Jagdamba P.,Konwar, Rituraj,Gupta, Gopal,Sharma, Vishnu L.. "Novel alkylphospholipid-DTC hybrids as promising agents against endocrine related cancers acting via modulation of Akt-pathway". . p. 638 - 647. Retrieved 2014.
• 2、 Singh,Tsao,Puranik. "Synthesis of metal-chelating polymerizable phospholipids". . p. 573 - 586. Retrieved 1995.
• 3、 -. "NOVEL CATIONIC CAROTENOID-BASED LIPIDS FOR CELLULAR NUCLEIC ACID UPTAKE". Page/Page column 42. . Retrieved 2014/05/24.