1-Piperidinecarboxylic acid, 4-[[[4-(4-amino-3-chlorophenoxy)-2-pyridinyl]amino]carbonyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[[[4-(4-amino-3-chlorophenoxy)-2-pyridinyl]amino]carbonyl]-, 1,1-dimethylethyl ester
CAS No.:417721-90-5
Molecular Formula:C22H27ClN4O4
Molecular Weight:446.934
Hs Code.:
Mol file:417721-90-5.mol

Synonyms:

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Chemical Property of 1-Piperidinecarboxylic acid, 4-[[[4-(4-amino-3-chlorophenoxy)-2-pyridinyl]amino]carbonyl]-, 1,1-dimethylethyl ester

Chemical Property:

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Technology Process of 1-Piperidinecarboxylic acid, 4-[[[4-(4-amino-3-chlorophenoxy)-2-pyridinyl]amino]carbonyl]-, 1,1-dimethylethyl ester

There total 2 articles about 1-Piperidinecarboxylic acid, 4-[[[4-(4-amino-3-chlorophenoxy)-2-pyridinyl]amino]carbonyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 417722-05-5
4-(4-Amino-3-chlorophenoxy)pyridin-2-ylamine

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 417721-90-5
4-(4-amino-3-chlorophenoxy)-2-{1-[(t-butoxycarbonyl)piperidin-4-yl]carbonylamino}pyridine

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield:

: 417722-05-5
4-(4-Amino-3-chlorophenoxy)pyridin-2-ylamine

: 56602-33-6
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 417721-90-5
4-(4-amino-3-chlorophenoxy)-2-{1-[(t-butoxycarbonyl)piperidin-4-yl]carbonylamino}pyridine

Guidance literature:: With triethylamine; In N-methyl-acetamide; water; ethyl acetate;

Reference yield: 85.2%

: 95262-10-5
3-((4-fluorophenyl)amino)-3-oxopropanoic acid

: 417721-90-5
4-(4-amino-3-chlorophenoxy)-2-{1-[(t-butoxycarbonyl)piperidin-4-yl]carbonylamino}pyridine

: 864245-15-8
4-(4-{3-Chloro-4-[2-(4-fluorophenylcarbamoyl)acetylamino]phenoxy}pyridin-2-ylcarbamoyl)piperidine-1-carboxylic acid t-butyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In DMF (N,N-dimethyl-formamide); at 50 ℃; for 1h;