Thieno[2,3-d]pyrimidine-5-carboxylic acid, 1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoro methyl)phenyl]methyl]-

Base Information

Chemical Name:Thieno[2,3-d]pyrimidine-5-carboxylic acid, 1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoro methyl)phenyl]methyl]-
CAS No.:418755-05-2
Molecular Formula:C20H19F3N2O4S
Molecular Weight:440.443
Hs Code.:
Mol file:418755-05-2.mol

Thieno[2,3-d]pyrimidine-5-carboxylic acid,
1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoro
methyl)phenyl]methyl]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Thieno[2,3-d]pyrimidine-5-carboxylic acid, 1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoro methyl)phenyl]methyl]-

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Technology Process of Thieno[2,3-d]pyrimidine-5-carboxylic acid, 1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoro methyl)phenyl]methyl]-

There total 4 articles about Thieno[2,3-d]pyrimidine-5-carboxylic acid, 1,2,3,4-tetrahydro-3-methyl-1-(2-methylpropyl)-2,4-dioxo-6-[[2-(trifluoro methyl)phenyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 372162-73-7
5-bromo-1-isobutyl-3-methyl-6-[2-(trifluoromethyl)benzyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 124-38-9,18923-20-1
carbon dioxide

: 418755-05-2
1-isobutyl-3-methyl-2,4-dioxo-6-(2-trifluoromethyl-benzyl)-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidine-5-carboxylic acid

Guidance literature:: 5-bromo-1-isobutyl-3-methyl-6-[2-(trifluoromethyl)benzyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione; With isopropylmagnesium chloride; In tetrahydrofuran;

carbon dioxide; at 0 ℃;
DOI:10.1016/j.bmcl.2006.01.024

Reference yield:

: 216686-77-0
3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 418755-05-2
1-isobutyl-3-methyl-2,4-dioxo-6-(2-trifluoromethyl-benzyl)-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / Br₂ / CH₂Cl₂

2.1: LDA / tetrahydrofuran / -78 °C

2.2: 71 percent / tetrahydrofuran

3.1: 83 percent / TFA; Et₃SiH

4.1: i-PrMgCl / tetrahydrofuran

4.2: 75 percent / 0 °C

With triethylsilane; bromine; isopropylmagnesium chloride; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2006.01.024

Reference yield:

: 259862-18-5
6-bromo-3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 418755-05-2
1-isobutyl-3-methyl-2,4-dioxo-6-(2-trifluoromethyl-benzyl)-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: 71 percent / tetrahydrofuran

2.1: 83 percent / TFA; Et₃SiH

3.1: i-PrMgCl / tetrahydrofuran

3.2: 75 percent / 0 °C

With triethylsilane; isopropylmagnesium chloride; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2006.01.024