2-Dimethylphenylsilylethanol

Base Information

• Chemical Name: 2-Dimethylphenylsilylethanol
• CAS No.: 41885-43-2
• Molecular Formula: C10H16OSi
• Molecular Weight: 180.31900
• DSSTox Substance ID: DTXSID70439202
• Nikkaji Number: J1.370.952A
• Mol file: 41885-43-2.mol

Synonyms:41885-43-2;2-dimethylphenylsilylethanol;2-(Dimethylphenylsilyl)ethanol;SCHEMBL1470831;2-(Dimethyl(phenyl)silyl)ethanol;DTXSID70439202;(2-hydroxyethyl)phenyldimethylsilane

Chemical Property of 2-Dimethylphenylsilylethanol

Chemical Property:

• PSA: 20.23000
• LogP: 1.59430
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 180.097041664
• Heavy Atom Count: 12
• Complexity: 128

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(CCO)C1=CC=CC=C1

Technology Process of 2-Dimethylphenylsilylethanol

There total 9 articles about 2-Dimethylphenylsilylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl [2-(dimethylphenyl)silyl]ethanoate (13950-56-6) → 1,1-dimethyl-1-phenyl-1-silapropan-3-ol (41885-43-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 1.5h; Heating;

DOI:10.1039/b201520j

Reference yield:

Dimethylphenylsilane (766-77-8) → 1,1-dimethyl-1-phenyl-1-silapropan-3-ol (41885-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Rh₂(OAc)4 / CH₂Cl₂ / 20 °C

2: 5 g / LiAlH₄ / diethyl ether / 1.5 h / Heating

With lithium aluminium tetrahydride; dirhodium tetraacetate; In diethyl ether; dichloromethane;

DOI:10.1039/b201520j

Reference yield:

tert-butyl α-(dimethylphenylsilyl)acetate (159826-55-8) → 1,1-dimethyl-1-phenyl-1-silapropan-3-ol (41885-43-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Yield given; 1.) r.t., 1 h, 2.) reflux, 2 h;

DOI:10.1021/jo00101a029

upstream raw materials:

vinyl acetate

Dimethylphenylsilane

2-(phenyldimethylsilyl)ethyl chloride

tert-butyl α-(dimethylphenylsilyl)acetate

Downstream raw materials:

2-(dimethylphenylsilyl)ethoxymethyl chloride

3-{4-[2-(dimethyl-phenyl-silanyl)-ethoxycarbonyl]-phenyl}-4,5-dihydro-isoxazole-5-carboxylic acid methyl ester

4-(hydroxyimino-methyl)-benzoic acid 2-(dimethyl-phenyl-silanyl)-ethyl ester

2-[dimethyl(phenyl)silyl]ethyl 3,5-dinitrobenzoate