2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID
• CAS No.: 41940-47-0
• Molecular Formula: C6H7NO2S
• Molecular Weight: 157.193
• Hs Code.: 2934999090
• Mol file: 41940-47-0.mol

Synonyms:2-amino-5-methyl thiophene-3-carboxylic acid;2-Amino-5-methyl-3-thiophenecarboxylic acid;

Chemical Property of 2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 331.556oC at 760 mmHg
• Flash Point: 154.32oC
• PSA: 91.56000
• Density: 1.429g/cm3
• LogP: 1.91810

Purity/Quality:

97% ^*data from raw suppliers

2-amino-5-methylthiophene-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID

There total 2 articles about 2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 2-amino-5-methylthiophene-3-carboxylate (19369-53-0) → 2-amino-5-methyl thiophene-3-carboxylic acid (41940-47-0)

Guidance literature:

methyl 2-amino-5-methylthiophene-3-carboxylate; With methanol; water; lithium hydroxide; In tetrahydrofuran; at 85 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

ethyl 2-amino-5-methylthiophene-3-carboxylate (4815-32-1) → 2-amino-5-methyl thiophene-3-carboxylic acid (41940-47-0)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 85 ℃; for 3h;

Reference yield: 55.0%

2-amino-5-methyl thiophene-3-carboxylic acid (41940-47-0) + triethyl 1,3,5-triazine-2,4,6-tricarboxylate (898-22-6) → 6-methylthieno[2,3-d]pyrimidine-2,4-dicarboxylate diethyl ester (1162684-77-6)

Guidance literature:

In acetic acid; N,N-dimethyl-formamide; at 80 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.03.180

upstream raw materials:

methyl 2-amino-5-methylthiophene-3-carboxylate

ethyl 2-amino-5-methylthiophene-3-carboxylate

Downstream raw materials:

6-methylthieno[2,3-d]pyrimidine-2,4-dicarboxylate diethyl ester

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