2-Propenoyl chloride, 2-bromo-

Base Information

• Chemical Name: 2-Propenoyl chloride, 2-bromo-
• CAS No.: 41965-71-3
• Molecular Formula: C₃H₂BrClO
• Molecular Weight: 169.405
• Mol file: 41965-71-3.mol

Synonyms:2-Propenoyl chloride,2-bromo;2-bromoacryloyl chloride;2-bromopropenoyl chloride;

Chemical Property of 2-Propenoyl chloride, 2-bromo-

Chemical Property:

• PSA: 17.07000
• LogP: 1.66040

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoyl chloride, 2-bromo-

There total 1 articles about 2-Propenoyl chloride, 2-bromo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-2-propenoic acid (10443-65-9) → α-bromoacryloyl chloride (41965-71-3)

Guidance literature:

With thionyl chloride;

Reference yield:

aniline (62-53-3) + α-bromoacryloyl chloride (41965-71-3) → N-phenyl-2-bromo-acrylic acid amide (39773-12-1)

Guidance literature:

With triethylamine; In acetonitrile;

DOI:10.1016/S0960-894X(02)00177-4

Reference yield:

4-chloro-aniline (106-47-8) + α-bromoacryloyl chloride (41965-71-3) → 2-Bromo-N-(4-chlorophenyl)-2-propenamide (35600-92-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃; for 2h;

DOI:10.1002/anie.202015083

upstream raw materials:

2-bromo-2-propenoic acid

Downstream raw materials:

2-[(2-Bromo-acryloyl)-(2-ethyl-6-methyl-phenyl)-amino]-thiopropionic acid S-methyl ester

N-phenyl-2-bromo-acrylic acid amide

4-(2-bromo-acryloylamino)-1-methyl-1H-pyrrole-2-carboxylic acid phenylamide

2-Bromo-N-(4-fluoro-phenyl)-acrylamide

Refernces

• 1、 Lee, Sumin,Rovis, Tomislav,Semakul, Natthawat. "Direct Regio- and Diastereoselective Synthesis of δ-Lactams from Acrylamides and Unactivated Alkenes Initiated by RhIII-Catalyzed C?H Activation". supporting information. p. 4965 - 4969. Retrieved 2020/02/20.
• 2、 White, James D.,Li, Yang,Kim, Jungchul,Terinek, Miroslav. "Cyclobutane Synthesis and Fragmentation. A Cascade Route to the Lycopodium Alkaloid (-)-Huperzine A". . p. 11806 - 11817. Retrieved 2015/12/11.