39773-12-1

Usage

### Main Properties

1. Molecular Formula: C9H8BrNO
2. Chemical Class: Acrylamides
3. Usage:
Synthesis of pharmaceuticals and agrochemicals
Reagent in organic synthesis
Manufacturing of polymers
4. Potential Applications:
Antimicrobial agent
Development of new drugs
Oncology research

Organic Compound

Belongs to the class of acrylamides.

Synthesis Uses

Commonly employed in the synthesis of various pharmaceuticals and agrochemicals.

Reagent

Utilized as a reagent in organic synthesis reactions.

Polymer Manufacturing

Plays a role in the production of polymers.

Antimicrobial Properties

Known for its potential as an antimicrobial agent.

Oncological Potential

Exhibits activity against various cancer cell lines, suggesting promise for oncology research and drug development.

2-Propenamide, 2-bromo-N-phenyl- appears to have a diverse range of applications, from pharmaceutical synthesis to potential oncological treatments, making it a subject of interest in various scientific fields.

Upstream product

• 90326-66-2 2,3-dibromo-propionic acid anilide 
• 60434-77-7 N-tert-butyl-N'-phenyl-sulfur diimide 
• 7148-74-5 2-Bromopropionyl chloride 
• 18791-02-1 2,3-dibromo-propionyl chloride 
• 62-53-3 aniline 
• 41965-71-3 α-bromoacryloyl chloride 

Downstream Products

• 95638-91-8 Methyl 2-<2-(Phenylcarbamoyl)aziridino>propionate 
• 95638-92-9 Methyl 2-<2-(Phenylcarbamoyl)aziridino>propionate 
• 64859-23-0 α-phenylacrylanilide 

Relevant academic research and scientific papers

Anionic Bisoxazoline Ligands Enable Copper-Catalyzed Asymmetric Radical Azidation of Acrylamides

Asymmetric radical azidation for the synthesis of chiral alkylazides remains a tremendous challenge in organic synthesis. We report here an unprecedented highly enantioselective radical azidation of acrylamides catalyzed by 1 mol % of a copper catalyst. The substrates were converted to the corresponding alkylazides in high yield with good-to-excellent enantioselectivity. Notably, employing an anionic cyano-bisoxazoline (CN-Box) ligand is crucial to generate a monomeric CuII azide species, rather than a dimeric CuII azide intermediate, for this highly enantioselective radical azidation.

Cytotoxic alpha-bromoacrylic derivatives of low molecular weight.

In vitro and in vivo activities of a small series of alpha-bromoacrylic derivatives of low molecular weight (MW) are described and compared with those of alpha-bromoacrylic derivatives of distamycin-like frames. Low MW compounds, when lacking of a strong basic moiety, are potent cytotoxics, while analogues bearing a strong basic moiety are not. This suggests the existence of an active transport mechanism for distamycin-derived cytotoxics characterized by strong basic amidino or guanidino moieties. Low MW compounds are inactive in vivo, possibly because of the metabolic lability of alpha-bromoacrylic moiety. The same moiety is however present in a series of potent anticancer distamycin-like minor groove binders, for example, PNU-166196 (brostallicin), a fact that underlines the features of the latter.

Nematicidal alkenanilides

A method is described for the control of nematodes in agricultural crops which comprises applying to the situs of infestation a nematicidal composition containing as active ingredient a compound of the formula STR1 wherein R1 and R2 are hydrogen, lower alkyl, or halogen, X is hydrogen or halogen, n is 1 or 2, Y is hydrogen, lower alkyl, halogen, trifluoromethyl, lower alkoxy, lower alkylthio, and nitro when n is 1, and halogen when n is 2, with the proviso that at least 1 of R1, R2, and X must be halogen. Preparation of active ingredient compounds is described, and nematicidal utility of compositions is exemplified.

ABSOLUTE CONFIGURATION OF DIASTEREOMERIC DERIVATIVES OF N-SUBSTITUTED AZIRIDINE-2-CARBOXYLIC ACIDS

Individual diastereomers of a number of anilides of N-substituted aziridine-2-carboxylic acids have been obtained.Conclusions regarding the spatial structure of the compounds indicated have been drawn on the basis of the 1H NMR, 15N NMR, and CD-spectra.

CYCLOADDITION REACTIONS OF KETENES TO SULFUR DIIMIDES

The reactions of sulfur diimides 1 with substituted ketenes 2, 5 were studied and the structures of the reaction products 3, 4, 6, 7 were cleared up; the syntheses of new sulfur diimides 9 a, 9 b are described.