2-hydroxy-N-(4-(trifluoromethyl)phenyl)benzamide

Base Information

Chemical Name:2-hydroxy-N-(4-(trifluoromethyl)phenyl)benzamide
CAS No.:42043-15-2
Molecular Formula:C14H10F3NO2
Molecular Weight:281.234
Hs Code.:
ChEMBL ID:CHEMBL64092
DSSTox Substance ID:DTXSID20414963
Nikkaji Number:J855.109J
Mol file:42043-15-2.mol

Synonyms:2-hydroxy-N-(4-(trifluoromethyl)phenyl)benzamide;42043-15-2;2-hydroxy-N-[4-(trifluoromethyl)phenyl]benzamide;CHEMBL64092;Benzamide, 2-hydroxy-N-[4-(trifluoromethyl)phenyl]-;SCHEMBL2698258;DTXSID20414963;AKOS009125482;N-(4-trifluoromethylphenyl)-2-hydroxy-benzamide;2-Hydroxy-N-(4-trifluoromethyl-phenyl)-benzamide

Suppliers and Price of 2-hydroxy-N-(4-(trifluoromethyl)phenyl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-hydroxy-N-(4-(trifluoromethyl)phenyl)benzamide

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:281.06636305
Heavy Atom Count:20
Complexity:338

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)C(F)(F)F)O

Technology Process of 2-hydroxy-N-(4-(trifluoromethyl)phenyl)benzamide

There total 5 articles about 2-hydroxy-N-(4-(trifluoromethyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 189687-77-2
N-(4-trifluoromethylphenyl)-2-acetoxy-benzamide

: 42043-15-2
N-(4-trifluoromethylphenyl)-2-hydroxy-benzamide

Guidance literature:: With 1H-imidazole; In methanol; for 2h; Ambient temperature;
DOI:10.1021/jm970039n

Reference yield:

: 288-32-4
1H-imidazole

: 189687-77-2
N-(4-trifluoromethylphenyl)-2-acetoxy-benzamide

: 42043-15-2
N-(4-trifluoromethylphenyl)-2-hydroxy-benzamide

Guidance literature:: In methanol;

Reference yield:

: 50-78-2,98201-60-6
aspirin

: 42043-15-2
N-(4-trifluoromethylphenyl)-2-hydroxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / Heating

2: Et₃N / CH₂Cl₂ / Ambient temperature

3: 65 percent / imidazole / methanol / 2 h / Ambient temperature

With 1H-imidazole; thionyl chloride; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm970039n