189687-77-2Relevant academic research and scientific papers
A new rational hypothesis for the pharmacophore of the active metabolite of leflunomide, a potent immunosuppressive drug
Bertolini, Giorgio,Aquino, Mario,Biffi, Mauro,D'Atri, Gaetano,Di Pierro, Francesco,Ferrario, Francesco,Mascagni, Paolo,Somenzi, Flavio,Zaliani, Andrea,Leoni, Flavio
, p. 2011 - 2016 (1997)
Leflunomide is one of the most promising disease-modifying antirheumatic drug now in clinical trials for the treatment of rheumatoid arthritis. Metabolic studies have indicated that leflunomide is rapidly processed in vivo to an active metabolite, A771726
Analogues of the active metabolite of leflunomide
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, (2008/06/13)
Analogues of the active metabolite of leflunomide, and to the use thereof as immunosuppressive and/or antinflammatory agents.
