Morpholine, 4-(cyclohexylthio)-

Base Information

• Chemical Name: Morpholine, 4-(cyclohexylthio)-
• CAS No.: 42267-53-8
• Molecular Formula: C10H19NOS
• Molecular Weight: 201.333
• Mol file: 42267-53-8.mol

Synonyms:

Chemical Property of Morpholine, 4-(cyclohexylthio)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Morpholine, 4-(cyclohexylthio)-

There total 4 articles about Morpholine, 4-(cyclohexylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

morpholine (110-91-8,99108-56-2) + N-(cyclohexylthio)-phthalimide (17796-82-6) → 4-(cyclohexylthio)morpholine (42267-53-8)

Guidance literature:

In 2-ethoxy-ethanol; at 50 ℃; for 2.5h; Microwave irradiation; Green chemistry;

DOI:10.1007/s00706-018-2261-4

Reference yield: 73.0%

morpholine (110-91-8,99108-56-2) + 1,2-dicyclohexyl disulfide (2550-40-5) → 4-(cyclohexylthio)morpholine (42267-53-8)

Guidance literature:

With silver nitrate; In methanol; at 25 ℃; for 1h;

DOI:10.1021/acs.orglett.0c02471

Reference yield:

Cyclohexanethiol (1569-69-3) → 4-(cyclohexylthio)morpholine (42267-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / acetonitrile / Heating

1.2: 2.5 h / 20 °C

1.3: 0.5 h

2.1: 2-ethoxy-ethanol / 2.5 h / 50 °C / Microwave irradiation; Green chemistry

With pyridine; In 2-ethoxy-ethanol; acetonitrile;

DOI:10.1007/s00706-018-2261-4

upstream raw materials:

Cyclohexanethiol

morpholine

N-(cyclohexylthio)-phthalimide

1,2-dicyclohexyl disulfide

Refernces

• 1、 Andresini, Michael,Spennacchio, Mauro,Romanazzi, Giuseppe,Ciriaco, Fulvio,Clarkson, Guy,Degennaro, Leonardo,Luisi, Renzo. "Synthesis of Sulfinamidines and Sulfinimidate Esters by Transfer of Nitrogen to Sulfenamides". supporting information. p. 7129 - 7134. Retrieved 2020/10/02.