Glycine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-, phenylmethyl ester

Base Information

Chemical Name:Glycine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-, phenylmethyl ester
CAS No.:42280-29-5
Molecular Formula:C23H28N2O5
Molecular Weight:412.486
Hs Code.:
Mol file:42280-29-5.mol

Synonyms:Boc-Phe-Gly-OBzl;[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoylamino]acetic acid benzyl ester;Boc-L-Phe-Gly-OBzl;

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Chemical Property of Glycine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-, phenylmethyl ester

Chemical Property:

PSA：93.73000
LogP:3.76380

Purity/Quality:

Safty Information:

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Technology Process of Glycine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-, phenylmethyl ester

There total 6 articles about Glycine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 2462-31-9
benzyl 2-aminoacetate hydrochloride

: 42280-29-5
[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoylamino]acetic acid benzyl ester

Guidance literature:: N-tert-butoxycarbonyl-L-phenylalanine; With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.166667h;

benzyl 2-aminoacetate hydrochloride; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1002/psc.2869

Reference yield: 94.3%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1738-76-7
glycine benzyl ester p-toluenesulfonic acid salt

: 42280-29-5
[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoylamino]acetic acid benzyl ester

Guidance literature:: N-tert-butoxycarbonyl-L-phenylalanine; With 4-methyl-morpholine; isobutyl chloroformate; In acetonitrile; at -15 ℃; for 0.25h;

glycine benzyl ester p-toluenesulfonic acid salt; With 4-methyl-morpholine; In N,N-dimethyl-formamide; acetonitrile; at -15 - 20 ℃;

Reference yield: 72.0%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: C₉H₁₂NO₂⁽¹⁺⁾*CF₃O₃S^(1-)

: 42280-29-5
[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoylamino]acetic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;
DOI:10.1039/c6ra13075e