CID 10878211

Base Information

• Chemical Name: CID 10878211
• CAS No.: 2462-31-9
• Molecular Formula: C9H11NO2^.HCl
• Molecular Weight: 201.653
• Hs Code.: 29224999
• Mol file: 2462-31-9.mol

Synonyms:SCHEMBL16620976

Chemical Property of CID 10878211

Chemical Property:

• Appearance/Colour: White to off-white powder
• Vapor Pressure: 0.0146mmHg at 25°C
• Melting Point: 138-140°C
• Refractive Index: 1.558
• Boiling Point: 245.5 °C at 760 mmHg
• Flash Point: 110.3 °C
• PSA: 52.32000
• Density: 1.132 g/cm³
• LogP: 2.19080
• Storage Temp.: −20°C
• Solubility.: DMSO, Methanol, Water
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 201.0556563
• Heavy Atom Count: 13
• Complexity: 142

Purity/Quality:

99% ^*data from raw suppliers

Glycine benzyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)C[NH3+].[Cl-]
• Uses: Potent crosslinking inhibitors.

Technology Process of CID 10878211

There total 8 articles about CID 10878211 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

BOC-glycine (4530-20-5) + benzyl alcohol (100-51-6,185532-71-2) → benzyl 2-aminoacetate hydrochloride (2462-31-9)

Guidance literature:

BOC-glycine; benzyl alcohol; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 ℃; Inert atmosphere;

With hydrogenchloride; In dichloromethane; ethyl acetate; at 0 ℃; Inert atmosphere;

DOI:10.1002/cjoc.202000133

Reference yield: 78.0%

Boc-glycine hydrochloride + benzyl bromide (100-39-0) → benzyl 2-aminoacetate hydrochloride (2462-31-9)

Guidance literature:

Boc-glycine hydrochloride; With caesium carbonate; In methanol;

benzyl bromide;

With hydrogenchloride; In diethyl ether;

DOI:10.1039/d1cc01285a

Reference yield: 78.0%

BOC-glycine (4530-20-5) + benzyl bromide (100-39-0) → benzyl 2-aminoacetate hydrochloride (2462-31-9)

Guidance literature:

BOC-glycine; With caesium carbonate; In methanol;

benzyl bromide; In methanol;

With hydrogenchloride; In methanol; diethyl ether;

upstream raw materials:

glycine

benzyl alcohol

tert-butoxycarbonylamino-acetic acid benzyl ester

BOC-glycine

Downstream raw materials:

carbobenzoxy-L-asparaginylglycine benzyl ester

dibenzyl 2,2'-(carbonylbis(azanediyl))diacetate

Cbz-Gly-Gly-OBn

Boc-Ser(Bzl)-Gly-OBzl

Refernces

• 1、 Kantharaju, Kamanna,Khatavi, Santosh Y.. "Eco-friendly synthesis of peptides using fmoc-amino acid chlorides as coupling agent under biphasic condition". . p. 699 - 707. Retrieved 2021/08/23.
• 2、 -. "N-transfer reagent and method for preparing the same and its application". Page/Page column 24; 49-50; 53-54. . Retrieved 2021/06/25.