1,8-Decadien-3-one, 10-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-hydroxy-1-iodo-7-methoxy-2, 6,8-trimethyl-, (1E,5S,6S,7R,8E)-

Base Information

Chemical Name:1,8-Decadien-3-one, 10-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-hydroxy-1-iodo-7-methoxy-2, 6,8-trimethyl-, (1E,5S,6S,7R,8E)-
CAS No.:423116-58-9
Molecular Formula:C30H41IO4Si
Molecular Weight:620.643
Hs Code.:
Mol file:423116-58-9.mol

Synonyms:

Suppliers and Price of 1,8-Decadien-3-one, 10-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-hydroxy-1-iodo-7-methoxy-2, 6,8-trimethyl-, (1E,5S,6S,7R,8E)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,8-Decadien-3-one, 10-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-hydroxy-1-iodo-7-methoxy-2, 6,8-trimethyl-, (1E,5S,6S,7R,8E)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,8-Decadien-3-one, 10-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-hydroxy-1-iodo-7-methoxy-2, 6,8-trimethyl-, (1E,5S,6S,7R,8E)-

There total 7 articles about 1,8-Decadien-3-one, 10-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-hydroxy-1-iodo-7-methoxy-2, 6,8-trimethyl-, (1E,5S,6S,7R,8E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 423116-55-6
[(E)-3-iodo-2-methyl-1-methyleneallyloxy]-trimethylsilane

: 874283-02-0
(E)-(2R,3R)-6-(tert-butyldiphenylsiloxy)-3-methoxy-2,4-dimethylhex-4-enal

: 423116-58-9
(1E,8E)-(5S,6S,7R)-10-(tert-butyldiphenylsiloxy)-5-hydroxy-1-iodo-7-methoxy-2,6,8-trimethyldeca-1,8-dien-3-one

Guidance literature:: With dimethylaluminum chloride; at -78 ℃;
DOI:10.1016/S0040-4039(01)02154-2

Reference yield:

: 423116-55-6
[(E)-3-iodo-2-methyl-1-methyleneallyloxy]-trimethylsilane

: 874283-02-0
(E)-(2R,3R)-6-(tert-butyldiphenylsiloxy)-3-methoxy-2,4-dimethylhex-4-enal

: (1E,8E)-(5R,6S,7R)-10-(tert-butyldiphenylsiloxy)-5-hydroxy-1-iodo-7-methoxy-2,6,8-trimethyldeca-1,8-dien-3-one

: 423116-58-9
(1E,8E)-(5S,6S,7R)-10-(tert-butyldiphenylsiloxy)-5-hydroxy-1-iodo-7-methoxy-2,6,8-trimethyldeca-1,8-dien-3-one

Guidance literature:: With boron trifluoride diethyl etherate; In toluene; at -85 ℃; for 72h; Title compound not separated from byproducts;
DOI:10.1039/b507570j

Reference yield:

: 186953-23-1
(E)-4-((tert-butyldiphenylsilyl)oxy)-2-methylbut-2-enal

: 423116-58-9
(1E,8E)-(5S,6S,7R)-10-(tert-butyldiphenylsiloxy)-5-hydroxy-1-iodo-7-methoxy-2,6,8-trimethyldeca-1,8-dien-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: Bu₂BOTf; i-Pr₂NEt / CH₂Cl₂ / 0.33 h / -10 °C

1.2: 87 percent / CH₂Cl₂ / 3 h / -78 - 0 °C

2.1: 89 percent / 2,6-di-tert-butyl-4-methylpyridine / CHCl₃ / 6 h / Heating

3.1: 79 percent / LiBH₄ / methanol; tetrahydrofuran; diethyl ether / 2 h / 0 °C

4.1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

5.1: Me₂AlCl / CH₂Cl₂; hexane / 0.08 h / -78 °C

5.2: CH₂Cl₂; hexane / 2 h / -78 °C

With lithium borohydride; 2,6-di-tert-butyl-4-methylpyridine; di-n-butylboryl trifluoromethanesulfonate; dimethylaluminum chloride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; chloroform; 1.2: Evans aldol reaction / 5.2: Mukaiyama aldol reaction;
DOI:10.1039/b507570j