186953-23-1Relevant articles and documents
An efficient total synthesis of (2E,4E,7R)-farnesa-2,4,10-triene from (R)-(+)-citronellal
Li, Jing,Liu, Zuosheng,Lan, Jiong,Li, Yulin
, p. 259 - 262 (1999)
(2E,4E,7R)-farnesa-2,4,10-triene(Caparratriene) (1), a novel sesquiterpene hydrocarbon with significant growth inhibitory activity against CEM leukemia cells, was first synthesized from (R)-(+)-citronellal (2) by employing titanium-induced intermolecular
The formal total synthesis of FR252921-An immunosuppressant
Yadav,Sengupta, Sandip
, p. 376 - 388 (2013/03/13)
The formal total synthesis of FR252921 is described. The key steps include the preparation of three fragments starting from 1,4-butanediol, (R)-malic acid, and prenol, respectively, followed by two consecutive peptide couplings of the three fragments. Other key steps involve an allene-type rearrangement or enyne isomerization to install the triene moiety, a Seebach methylation, a Julia olefination to construct the trisubstituted diene unit, and an enzymatic resolution strategy to generate the C-18 stereocenter.
Intramolecular Formal oxa-[3 + 3] Cycloaddition Approach to the ABD System of Phomactin A
Cole, Kevin P.,Hsung, Richard P.
, p. 4843 - 4846 (2007/10/03)
(Equation Presented) The ABD-ring of phomactin A was synthesized using an intramolecular formal oxa-[3 + 3] cycloaddion of an α,β-unsaturated iminium salt tethered to a 1,3-diketone. This represents the first time that the 12-membered ring has been formed