2-Oxazolidinone, 3-[(2S,3R,5R)-5-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]-3-hydroxy -2-methyl-1-oxo-6-heptenyl]-4-methyl-5-phenyl-, (4S,5R)-

Base Information

Chemical Name:2-Oxazolidinone, 3-[(2S,3R,5R)-5-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]-3-hydroxy -2-methyl-1-oxo-6-heptenyl]-4-methyl-5-phenyl-, (4S,5R)-
CAS No.:423117-82-2
Molecular Formula:C36H45NO5Si
Molecular Weight:599.842
Hs Code.:
Mol file:423117-82-2.mol

2-Oxazolidinone,
3-[(2S,3R,5R)-5-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]-3-hydroxy
-2-methyl-1-oxo-6-heptenyl]-4-methyl-5-phenyl-, (4S,5R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Oxazolidinone, 3-[(2S,3R,5R)-5-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]-3-hydroxy -2-methyl-1-oxo-6-heptenyl]-4-methyl-5-phenyl-, (4S,5R)-

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Technology Process of 2-Oxazolidinone, 3-[(2S,3R,5R)-5-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]-3-hydroxy -2-methyl-1-oxo-6-heptenyl]-4-methyl-5-phenyl-, (4S,5R)-

There total 7 articles about 2-Oxazolidinone, 3-[(2S,3R,5R)-5-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]-3-hydroxy -2-methyl-1-oxo-6-heptenyl]-4-methyl-5-phenyl-, (4S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 77877-20-4,116382-72-0,143654-01-7
(4S,5R)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one

: 423117-81-1
(α)-3-[2-(tert-butyldiphenylsilanyloxy)-ethyl]-pent-4-enal

: 423117-83-3
(2'S,3'R,4R,5S,5'R)-3-{5'-[2''-(tert-butyldiphenylsilanyloxy)-ethyl]-3'-hydroxy-2'-methylhept-6'-enoyl}-4-methyl-5-phenyloxazolidin-2-one

: 423117-82-2
(2'S,3'R,4R,5S,5'S)-3-{5'-[2''-(tert-butyldiphenylsilanyloxy)-ethyl]-3'-hydroxy-2'-methylhept-6'-enoyl}-4-methyl-5-phenyloxazolidin-2-one

Guidance literature:: (4S,5R)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one; With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 0.5h;

(α)-3-[2-(tert-butyldiphenylsilanyloxy)-ethyl]-pent-4-enal; In dichloromethane; at -78 - 20 ℃; for 2h;
DOI:10.1039/b507570j

Reference yield:

: 256494-25-4
(E)-ethyl 5-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)pent-2-enoate

: 423117-82-2
(2'S,3'R,4R,5S,5'S)-3-{5'-[2''-(tert-butyldiphenylsilanyloxy)-ethyl]-3'-hydroxy-2'-methylhept-6'-enoyl}-4-methyl-5-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 93 percent / DIBAL-H / toluene; CH₂Cl₂ / 1 h / -78 °C

2.1: 78 percent / Hg(O₂CCF₃)2 / 8 h / 20 °C

3.1: 97 percent / toluene / 36 h / 170 °C

4.1: Bu₂BOTf; i-Pr₂NEt / CH₂Cl₂ / 0.5 h / -78 °C

4.2: 40 percent / CH₂Cl₂ / 2 h / -78 - 20 °C

With di-n-butylboryl trifluoromethanesulfonate; mercury(II) trifluoroacetate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; 3.1: Claisen rearrangement / 4.2: Evans aldol reaction;
DOI:10.1039/b507570j

Reference yield:

: tert-butyldiphenyl-(5-vinylpent-3-enyloxy)-silane

: 423117-82-2
(2'S,3'R,4R,5S,5'S)-3-{5'-[2''-(tert-butyldiphenylsilanyloxy)-ethyl]-3'-hydroxy-2'-methylhept-6'-enoyl}-4-methyl-5-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / toluene / 36 h / 170 °C

2.1: Bu₂BOTf; i-Pr₂NEt / CH₂Cl₂ / 0.5 h / -78 °C

2.2: 40 percent / CH₂Cl₂ / 2 h / -78 - 20 °C

With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; 1.1: Claisen rearrangement / 2.2: Evans aldol reaction;
DOI:10.1039/b507570j