2-HYDROXY-6-ETHYLPYRIDINE-3-CARBONITRILE

Base Information

• Chemical Name: 2-HYDROXY-6-ETHYLPYRIDINE-3-CARBONITRILE
• CAS No.: 4241-20-7
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.16200
• Hs Code.: 2933399090
• Mol file: 4241-20-7.mol

Synonyms:6-ETHYL-2-HYDROXYNICOTINONITRILE;6-ethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile;2-HYDROXY-6-ETHYLPYRIDINE-3-CARBONITRILE;6-ETHYL-2-HYDROXYPYRIDINE-3-CARBONITRILE;6-ethyl-1,2-dihydro-2-oxo-3-pyridinecarbonitrile;

Chemical Property of 2-HYDROXY-6-ETHYLPYRIDINE-3-CARBONITRILE

Chemical Property:

• PSA: 56.91000
• LogP: 1.22128

Purity/Quality:

98%min ^*data from raw suppliers

2-HYDROXY-6-ETHYLPYRIDINE-3-CARBONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-HYDROXY-6-ETHYLPYRIDINE-3-CARBONITRILE

There total 14 articles about 2-HYDROXY-6-ETHYLPYRIDINE-3-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-ethyl-2,6,6-tricyano-2,4-hexadienamide ammonium salt → 3-cyano-6-ethyl-2(1H)-pyridinone (4241-20-7)

Guidance literature:

With hydrogenchloride; In water; Heating;

DOI:10.1021/jo991121o

Reference yield: 70.0%

cis-β-Aminovinyl-ethylketon (50874-61-8) + malononitrile (109-77-3) → 3-cyano-6-ethyl-2(1H)-pyridinone (4241-20-7)

Guidance literature:

In ethanol; at 80 ℃; for 120h;

DOI:10.1021/jo991121o

Reference yield: 56.0%

1-hydroxy-6-methylpyridine-3-carbonitrile + methyl iodide (74-88-4) → 2-Hydroxy-3-cyan-6-ethyl-pyridin (4241-20-7)

Guidance literature:

With sodium hydroxide; sodium chloride; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; water;

upstream raw materials:

methyl iodide

5-Cyano-2-ethyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid

cis-β-Aminovinyl-ethylketon

malononitrile

Downstream raw materials:

C₂₂H₂₀N₄S

C₂₄H₂₃N₅OS

C₂₂H₂₀N₄OS

2-chloro-6-ethyl-nicotinonitrile

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