Acrylophenone, 2',4'-dihydroxy-3-(m-hydroxy-p-methoxyphenyl)-

Base Information

Chemical Name:Acrylophenone, 2',4'-dihydroxy-3-(m-hydroxy-p-methoxyphenyl)-
CAS No.:13323-67-6
Molecular Formula:C16H14 O5
Molecular Weight:286.284
Hs Code.:
Nikkaji Number:J437.478I
Wikidata:Q76305628
Metabolomics Workbench ID:26589
ChEMBL ID:CHEMBL4791427
Mol file:13323-67-6.mol

Synonyms:4-O-methylbutein

Suppliers and Price of Acrylophenone, 2',4'-dihydroxy-3-(m-hydroxy-p-methoxyphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of Acrylophenone, 2',4'-dihydroxy-3-(m-hydroxy-p-methoxyphenyl)-

Chemical Property:

Vapor Pressure:5.97E-13mmHg at 25°C
Melting Point:198.5-200.5℃
Boiling Point:555.6°C at 760 mmHg
PKA:7.33±0.35(Predicted)
Flash Point:210.6°C
PSA：86.99000
Density:1.369g/cm³
LogP:2.70810
XLogP3:3.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:286.08412354
Heavy Atom Count:21
Complexity:381

Purity/Quality:: ≥98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C=CC(=O)C2=C(C=C(C=C2)O)O)O
Isomeric SMILES:COC1=C(C=C(C=C1)/C=C/C(=O)C2=C(C=C(C=C2)O)O)O

Technology Process of Acrylophenone, 2',4'-dihydroxy-3-(m-hydroxy-p-methoxyphenyl)-

There total 6 articles about Acrylophenone, 2',4'-dihydroxy-3-(m-hydroxy-p-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1417453-13-4
2’,3,4’-triisopropoxy-4-methoxychalcone

: 13323-67-6
2’,3,4’-trihydroxy-4-methoxychalcone

Guidance literature:: With boron trichloride; In hexane; dichloromethane; at -78 - 0 ℃; for 3.5h; Inert atmosphere;
DOI:10.1039/c2ob27163j

Reference yield:

: 621-59-0
isovanillin

: 89-84-9
2',4'-dihydroxy-4-acetophenone

: 13323-67-6
2’,3,4’-trihydroxy-4-methoxychalcone

: 76426-28-3
7-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one

Guidance literature:: With potassium hydroxide; In isopropyl alcohol; at 80 ℃; Reflux;
DOI:10.3390/molecules25061382

Reference yield:

: 728911-59-9
2,4-diisopropoxyacetophenone

: 13323-67-6
2’,3,4’-trihydroxy-4-methoxychalcone

Guidance literature:: Multi-step reaction with 2 steps

1: barium hydroxide octahydrate / methanol / 50 °C / Inert atmosphere

2: boron trichloride / dichloromethane; hexane / 3.5 h / -78 - 0 °C / Inert atmosphere

With barium hydroxide octahydrate; boron trichloride; In methanol; hexane; dichloromethane; 1: |Claisen-Schmidt Condensation;
DOI:10.1039/c2ob27163j