4-(4-Ethoxyphenoxy)aniline

Base Information

• Chemical Name: 4-(4-Ethoxyphenoxy)aniline
• CAS No.: 51690-67-6
• Molecular Formula: C14H15 N O2
• Molecular Weight: 229.27
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID20965965
• Wikidata: Q82948294
• Mol file: 51690-67-6.mol

Synonyms:4-(4-ethoxyphenoxy)aniline;51690-67-6;Benzenamine, 4-(4-ethoxyphenoxy)-;4-(4-ETHOXYPHENOXY)ANILINEHYDROCHLORIDE;Enamine_005855;SCHEMBL11088120;DTXSID20965965;HMS1410K03;BCA69067;STL355045;AKOS000101562;IDI1_008090;CS-0247018;EN300-35321;Z204534046

Chemical Property of 4-(4-Ethoxyphenoxy)aniline

Chemical Property:

• Vapor Pressure: 9.8E-06mmHg at 25°C
• Boiling Point: 372.2°C at 760 mmHg
• Flash Point: 196.8°C
• PSA: 44.48000
• Density: 1.13g/cm³
• LogP: 4.04100
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 229.110278721
• Heavy Atom Count: 17
• Complexity: 206

Purity/Quality:

98%min ^*data from raw suppliers

4-(4-Ethoxyphenoxy)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=C(C=C1)OC2=CC=C(C=C2)N

Technology Process of 4-(4-Ethoxyphenoxy)aniline

There total 6 articles about 4-(4-Ethoxyphenoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 4'-Ethoxy-4-aminodiphenylether (51690-67-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 20 - 80 °C / Inert atmosphere

2: hydrogen bromide / 4 h / Inert atmosphere; Reflux

3: potassium carbonate; potassium iodide / acetonitrile / Inert atmosphere; Reflux

4: tin(II)chloride dihydrate; ethanol / 1 h / 70 °C / Inert atmosphere

With tin(II)chloride dihydrate; ethanol; hydrogen bromide; sodium hydride; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.2174/157018012799859909

Reference yield:

1-methoxy-4-(4-nitrophenoxy)benzene (6337-24-2) → 4'-Ethoxy-4-aminodiphenylether (51690-67-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen bromide / 4 h / Inert atmosphere; Reflux

2: potassium carbonate; potassium iodide / acetonitrile / Inert atmosphere; Reflux

3: tin(II)chloride dihydrate; ethanol / 1 h / 70 °C / Inert atmosphere

With tin(II)chloride dihydrate; ethanol; hydrogen bromide; potassium carbonate; potassium iodide; In acetonitrile;

DOI:10.2174/157018012799859909

Reference yield:

4-methoxy-phenol (150-76-5) → 4'-Ethoxy-4-aminodiphenylether (51690-67-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 20 - 80 °C / Inert atmosphere

2: hydrogen bromide / 4 h / Inert atmosphere; Reflux

3: potassium carbonate; potassium iodide / acetonitrile / Inert atmosphere; Reflux

4: tin(II)chloride dihydrate; ethanol / 1 h / 70 °C / Inert atmosphere

With tin(II)chloride dihydrate; ethanol; hydrogen bromide; sodium hydride; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.2174/157018012799859909

upstream raw materials:

1-methoxy-4-(4-nitrophenoxy)benzene

4-(4-nitrophenoxy)phenol

4-ethoxy-4'-nitrodiphenyloxide

4-methoxy-phenol

Refernces