p-(p-Nitrophenoxy)anisole

Base Information

• Chemical Name: p-(p-Nitrophenoxy)anisole
• CAS No.: 6337-24-2
• Molecular Formula: C13H11 N O4
• Molecular Weight: 245.235
• Hs Code.: 2909309090
• European Community (EC) Number: 228-722-3
• NSC Number: 39657
• UNII: CF84DKH6XK
• DSSTox Substance ID: DTXSID50212772
• Nikkaji Number: J206.936I
• Wikidata: Q83087969
• Mol file: 6337-24-2.mol

Synonyms:1-methoxy-4-(4-nitrophenoxy)benzene;6337-24-2;p-(p-Nitrophenoxy)anisole;1-(4-methoxyphenoxy)-4-nitrobenzene;CF84DKH6XK;4-Methoxy-4'-nitrodiphenyl ether;EINECS 228-722-3;NSC-39657;NSC39657;Maybridge1_007935;UNII-CF84DKH6XK;Oprea1_206414;SCHEMBL177626;C9-H14-N-O3.Na;HMS564A15;DTXSID50212772;CCG-41684;MFCD00443498;NSC 39657;STK366774;1-(4-nitrophenoxy)-4-methoxybenzene;4-(4-nitrophenoxy)phenol methyl ether;AKOS000280166;Benzene, 1-methoxy-4-(4-nitrophenoxy)-;CS-0326768;SR-01000631741-1;2,4-Oxazolidinedione, 5-(2,2-dimethylpropyl)-5-methyl-, sodium salt

Chemical Property of p-(p-Nitrophenoxy)anisole

Chemical Property:

• Vapor Pressure: 4.74E-05mmHg at 25°C
• Boiling Point: 360°C at 760 mmHg
• Flash Point: 155.5°C
• PSA: 64.28000
• Density: 1.252g/cm³
• LogP: 3.91890
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 245.06880783
• Heavy Atom Count: 18
• Complexity: 263

Purity/Quality:

99% ^*data from raw suppliers

1-Methoxy-4-(4-nitrophenoxy)benzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)OC2=CC=C(C=C2)[N+](=O)[O-]

Technology Process of p-(p-Nitrophenoxy)anisole

There total 40 articles about p-(p-Nitrophenoxy)anisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxy-phenol (150-76-5) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 1-methoxy-4-(4-nitrophenoxy)benzene (6337-24-2)

Guidance literature:

With TMS-NEt₂; phosphazene base t-Bu-P₄; In hexane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2007.10.031

Reference yield: 98.0%

4-methoxy-phenol (150-76-5) + para-nitrophenyl bromide (586-78-7) → 1-methoxy-4-(4-nitrophenoxy)benzene (6337-24-2)

Guidance literature:

With caesium carbonate; In ethanol; at 80 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.catcom.2014.09.006

Reference yield: 91.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 4-chloromethoxybenzene (623-12-1) → 1-methoxy-4-(4-nitrophenoxy)benzene (6337-24-2)

Guidance literature:

With copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 20 - 110 ℃;

DOI:10.1021/jo901462g

upstream raw materials:

1-bromo-4-methoxy-benzene

4-nitro-phenol

potassium p-methoxyphenolate

4-chlorobenzonitrile

Downstream raw materials:

4-(4-nitrophenoxy)phenol

4-(4'-methoxyphenoxy)aniline

4-(4-methoxyphenoxy)aniline hydrochloride

4-(4-methoxyphenyl)phenyl azide